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Article
Open AccessThe role of targeting CDK4/6 in cancer immunotherapy
Cyclin-dependent kinase 4/6 (CDK4/6) acts as a crucial point of regulation in the G1-to-S transition in the cell division cycle, its aberrant activation was found in various human cancers, leading to abnormal ...
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Article
Open AccessGenome-wide analysis of the switchgrass YABBY family and functional characterization of PvYABBY14 in response to ABA and GA stress in Arabidopsis
The small YABBY plant-specific transcription factor has a prominent role in regulating plant growth progress and responding to abiotic stress.
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Article
Open AccessSOX on tumors, a comfort or a constraint?
The sex-determining region Y (SRY)-related high-mobility group (HMG) box (SOX) family, composed of 20 transcription factors, is a conserved family with a highly homologous HMG domain. Due to their crucial role...
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Article
Open AccessTranscription factor BACH1 in cancer: roles, mechanisms, and prospects for targeted therapy
Transcription factor BTB domain and CNC homology 1 (BACH1) belongs to the Cap ‘n’ Collar and basic region Leucine Zipper (CNC-bZIP) family. BACH1 is widely expressed in mammalian tissues, where it regulates ep...
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Article
Large Active Faults and the Wharton Basin Intraplate Earthquakes in the Eastern Indian Ocean
In recent years, great earthquakes occurred within the Wharton Basin in the eastern Indian Ocean, and they have been associated with active faulting on the ancient oceanic crust. Large seismogenic faults were ...
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Article
Modeling and Simulation of a Shock Driving Gas Jet Laden with Dense Extinguishant Particles Through a Tube with a Tail Nozzle
In this study, we proposed a new concept of shock wave driving fire extinguishing system (SWDES), which works using a pulsed shock-induced gas-particle jet. We conducted modeling and simulations of shock-induc...
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Article
Open AccessSecurity Energy Efficiency Analysis of CR-NOMA Enabled IoT Systems for Edge-cloud Environment
With the development of the Internet of Things (IoT), more and more devices are connected in edge-cloud environment, and spectrum scarcity has become a major bottleneck for the employment of IoT devices in the...
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Article
Reduction of the levels of 5-hydroxymethylfurfural and advanced glycation end products in milk by the combination of high pressure and moderate heat pre-incubation
Traditional thermal processing often denatures protein, causing loss of active ingredients and nutrients in dairy products, even the formation of 5-hydroxymethylfurfural (5-HMF) and advanced glycation end prod...
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Article
Open AccessHGF-mediated elevation of ETV1 facilitates hepatocellular carcinoma metastasis through upregulating PTK2 and c-MET
Metastasis is a major determinant of death in patients with hepatocellular carcinoma (HCC). Dissecting key molecular mediators that promote this malignant feature may help yield novel therapeutic insights. Her...
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Article
Erratum to “Numerical study on the shock vector control performance in a de Laval nozzle with single or dual injection ports”
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Article
Specific generation of nitric oxide in mitochondria of cancer cell for selective oncotherapy
Nitric oxide (NO) gas therapy, especially, L-arginine (L-Arg)-based NO treatment strategies have attracted extensive attention in the field of oncotherapy. However, current strategies are unable to differentia...
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Article
T-box transcription factor 19 promotes hepatocellular carcinoma metastasis through upregulating EGFR and RAC1
The effect of targeted therapy for metastatic hepatocellular carcinoma (HCC) is still unsatisfactory. Exploring the underlying mechanism of HCC metastasis is favorable to provide new therapeutic strategies. T-...
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Article
Open AccessCorrection to: ONECUT2 facilitates hepatocellular carcinoma metastasis by transcriptionally upregulating FGF2 and ACLY
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Article
Open AccessONECUT2 facilitates hepatocellular carcinoma metastasis by transcriptionally upregulating FGF2 and ACLY
Metastasis is the predominant reason for high mortality of hepatocellular carcinoma (HCC) patients. It is critical to explore the molecular mechanism underlying HCC metastasis. Here, we reported that transcrip...
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Article
Open AccessIGF1-mediated HOXA13 overexpression promotes colorectal cancer metastasis through upregulating ACLY and IGF1R
Metastasis is the major reason for the high mortality of colorectal cancer (CRC) patients and its molecular mechanism remains unclear. Here, we report a novel role of Homeobox A13 (HOXA13), a member of the Hom...
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Article
Two-Photon Fluorescence Study of Olive Oils at Different Excitation Wavelengths
Two-photon fluorescence (TPF) of olive oils is discovered and observed experimentally for the first time. Variations of the single-photon fluorescence (SPF) and TPF with the excitation wavelength are investiga...
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Article
Open AccessFOXC1 promotes HCC proliferation and metastasis by Upregulating DNMT3B to induce DNA Hypermethylation of CTH promoter
Forkhead box C1 (FOXC1), as a member of the FOX family, is important for promote HCC invasion and metastasis. FOX family protein lays a pivotal role in metabolism. ROS is involved in tumor progression and is a...
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Article
Spatial Pattern and Development of Protected Areas in the North-south Transitional Zone of China
The north-south transitional zone in China mainly consists of the Qinling-Daba Mountains. It is the most important West-East geo-ecological space in China, containing protected areas vital for biodiversity con...
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Article
Understanding the dynamical-microphysical-electrical processes associated with severe thunderstorms over the Bei**g metropolitan region
The Dynamical-microphysical-electrical Processes in Severe Thunderstorms and Lightning Hazards (STORM973) project conducted coordinated comprehensive field observations of thunderstorms in the Bei**g metropol...
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Chapter and Conference Paper
Migration-Based Service Allocation Optimization in Dynamic IoT Networks
Considering the resource-hungry and capability-constraint of Internet of Things (IoT) nodes, their functionalities, which are encapsulated as containerized IoT services, are composed to satisfy user requests. IoT
