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Open AccessIdentification of necroptosis-related gene signatures for predicting the prognosis of ovarian cancer
Ovarian cancer (OC) is one of the most prevalent and fatal malignant tumors of the female reproductive system. Our research aimed to develop a prognostic model to assist inclinical treatment decision-making.Ut...
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Open AccessPeripheral blood transcriptomic analysis identifies potential inflammation and immune signatures for central retinal artery occlusion
Central retinal artery occlusion (CRAO) is an acute retinal ischaemic disease, but early diagnosis is challenging due to a lack of biomarkers. Blood samples were collected from CRAO patients and cataract patie...
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Article
Open AccessAnalysis of residential satisfaction in the conversion of Bei**g’s stock buildings into rental housing
This paper investigates the residential satisfaction levels of tenants living in rental housing converted from non-residential stock buildings in Bei**g. A stratified random sampling method was used to select...
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Article
Open AccessGut microbiota-derived tryptamine and phenethylamine impair insulin sensitivity in metabolic syndrome and irritable bowel syndrome
The incidence of metabolic syndrome is significantly higher in patients with irritable bowel syndrome (IBS), but the mechanisms involved remain unclear. Gut microbiota is causatively linked with the developmen...
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Open AccessNanovesicles loaded with a TGF-β receptor 1 inhibitor overcome immune resistance to potentiate cancer immunotherapy
The immune-excluded tumors (IETs) show limited response to current immunotherapy due to intrinsic and adaptive immune resistance. In this study, it is identified that inhibition of transforming growth factor-β...
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Open AccessExtraction, structural characterization, and biological activities of a new glucan from Codonopsis pilosula
In this study, a powerful and rapid aqueous two-phase system (ATPS) method was used to extract polysaccharides from Codonopsis pilosula. The ATPS process was investigated with response surface methodology (RSM). ...
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Article
Open AccessSolid state ionics enabled ultra-sensitive detection of thermal trace with 0.001K resolution in deep sea
The deep sea remains the largest uncharted territory on Earth because it’s eternally dark under high pressure and the saltwater is corrosive and conductive. The harsh environment poses great difficulties for t...
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Open AccessClose relatives of MERS-CoV in bats use ACE2 as their functional receptors
Middle East respiratory syndrome coronavirus (MERS-CoV) and several bat coronaviruses use dipeptidyl peptidase-4 (DPP4) as an entry receptor1–4. However, the receptor for NeoCoV—the closest known MERS-CoV relativ...
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Open AccessSystematic strategies for develo** phage resistant Escherichia coli strains
Phages are regarded as powerful antagonists of bacteria, especially in industrial fermentation processes involving bacteria. While bacteria have developed various defense mechanisms, most of which are effectiv...
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Article
Open AccessHuman pointing motion during interaction with an autonomous blimp
We investigate the interaction between a human and a miniature autonomous blimp using a wand as pointing device. The wand movement generated by the human is followed by the blimp through a tracking controller....
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Open AccessSuperstretchable, yet stiff, fatigue-resistant ligament-like elastomers
Ligaments are flexible and stiff tissues around joints to support body movements, showing superior toughness and fatigue-resistance. Such a combination of mechanical properties is rarely seen in synthetic elas...
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Open AccessTough, stable and self-healing luminescent perovskite-polymer matrix applicable to all harsh aquatic environments
Gelatinous underwater invertebrates such as jellyfish have organs that are transparent, luminescent and self-healing, which allow the creatures to navigate, camouflage themselves and, indeed, survive in aquati...
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Open AccessMultiple pollutants in groundwater near an abandoned Chinese fluorine chemical park: concentrations, correlations and health risk assessments
Contamination and adverse effects from various pollutants often appear in abandoned industrial regions. Thus, nine groundwater samples were collected from the vicinity of the fluorochemical industry in Fuxin C...
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Open AccessSPP1 overexpression is associated with poor outcomes in ALK fusion lung cancer patients without receiving targeted therapy
The screening of non-small cell lung cancer (NSCLC) tumors for anaplastic lymphoma receptor tyrosine kinase (ALK) gene rearrangements is important because of the dramatically favorable therapy response to ALK ...
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Open AccessAuthor Correction: Zearalenone altered the cytoskeletal structure via ER stress– autophagy– oxidative stress pathway in mouse TM4 Sertoli cells
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessExtreme nonlinear strong-field photoemission from carbon nanotubes
Strong-field photoemission produces attosecond (10−18 s) electron pulses that are synchronized to the waveform of the incident light. This nonlinear photoemission lies at the heart of current attosecond technolog...
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Open AccessExpression of PD-1/PD-L1 in primary breast tumours and metastatic axillary lymph nodes and its correlation with clinicopathological parameters
The aim of this study was to compare the expression of PD-1/PD-L1 in primary breast tumours to that in metastatic axillary lymph nodes and to determine the correlation between the PD-1/PD-L1 status and clinico...
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Open AccessN-Phenylquinazolin-2-amine Yhhu4952 as a novel promotor for oligodendrocyte differentiation and myelination
Oligodendrocytes are a type of glial cells that ensheath multiple neuronal axons and form myelin. Under pathological conditions, such as multiple sclerosis (MS), inflammatory damage to myelin and oligodendrocy...
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Open AccessZearalenone altered the cytoskeletal structure via ER stress- autophagy- oxidative stress pathway in mouse TM4 Sertoli cells
The aim of this study was to investigate the molecular mechanisms of the destruction of cytoskeletal structure by Zearalenone (ZEA) in mouse-derived TM4 cells. In order to investigate the role of autophagy, ox...
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Open AccessNonylphenol aggravates non-alcoholic fatty liver disease in high sucrose-high fat diet-treated rats
Exposure to environmental endocrine disruptors (EEDs) contributes to the pathogenesis of many metabolic disorders. Here, we have analyzed the effect of the EED-nonylphenol (NP) on the promotion of non-alcoholi...