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Immovable Pipeline Decompression and Augmented Injection Integrated Technology Apply to Low Permeability Reservoir

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  1. Article

    OL3, a novel low-absorbed TGR5 agonist with reduced side effects, lowered blood glucose via dual actions on TGR5 activation and DPP-4 inhibition

    TGR5 agonists stimulate intestinal glucagon-like peptide-1 (GLP-1) release, but systemic exposure causes unwanted side effects, such as gallbladder filling. In the present study, linagliptin, a DPP-4 inhibitor...

    Shan-yao Ma, Meng-meng Ning, Qing-an Zou, Ying Feng… in Acta Pharmacologica Sinica (2016)

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  2. Article

    Open Access

    Intestinally-targeted TGR5 agonists equipped with quaternary ammonium have an improved hypoglycemic effect and reduced gallbladder filling effect

    TGR5 activation of enteroendocrine cells increases glucagon-like peptide 1 (GLP-1) release, which maintains glycemic homeostasis. However, TGR5 activation in the gallbladder and heart is associated with severe...

    Hua Cao, Zhi-**ang Chen, Kai Wang, Meng-Meng Ning, Qing-An Zou… in Scientific Reports (2016)

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  3. Article

    Emodin, an 11β-hydroxysteroid dehydrogenase type 1 inhibitor, regulates adipocyte function in vitro and exerts anti-diabetic effect in ob/ob mice

    Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a potent and selective inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) with the ability to ameliorate metabolic disorders in diet-induced obes...

    Yue-**g Wang, Su-ling Huang, Ying Feng, Meng-meng Ning… in Acta Pharmacologica Sinica (2012)

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