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  1. No Access

    Article

    TOX deficiency facilitates the differentiation of IL-17A-producing γδ T cells to drive autoimmune hepatitis

    The specification of the αβ/γδ lineage and the maturation of medullary thymic epithelial cells (mTECs) coordinate central tolerance to self-antigens. However, the mechanisms underlying this biological process ...

    Qifeng He, Yijun Lu, Wenfang Tian, Runqiu Jiang… in Cellular & Molecular Immunology (2022)

  2. Article

    Open Access

    Real-world data analysis of immune checkpoint inhibitors in stage III-IV adenocarcinoma and squamous cell carcinoma

    This study was designed to investigate the clinical application, efficacy, and safety of immune checkpoint inhibitors (ICIs) in the treatment of lung cancer in the real world.

    Meiling Sun, Huaijun Ji, Ning Xu, Peng Jiang, Tao Qu, Yu Li in BMC Cancer (2022)

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  3. Article

    Open Access

    Alcoholic fatty liver disease inhibited the co-expression of Fmo5 and PPARα to activate the NF-κB signaling pathway, thereby reducing liver injury via inducing gut microbiota disturbance

    Alcohol-induced intestinal dysbiosis disrupts and inflammatory responses are essential in the development of alcoholic fatty liver disease (AFLD). Here, we investigated the effects of Fmo5 on changes in enteri...

    Lingjian Kong, **g Chen, **aoli Ji… in Journal of Experimental & Clinical Cancer … (2021)

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  4. No Access

    Article

    Combination of NAD+ and NADPH Offers Greater Neuroprotection in Ischemic Stroke Models by Relieving Metabolic Stress

    Both reduced nicotinamide adenine dinucleotide phosphate (NADPH) and β-nicotinamide adenine dinucleotide hydrate (NAD+) have been reported to have potent neuroprotective effects against ischemic neuronal injury. ...

    Qiao Huang, Meiling Sun, Mei Li, Dingmei Zhang, Feng Han… in Molecular Neurobiology (2018)

  5. Article

    Open Access

    Prognostic Value of microRNA-9 in Various Cancers: a Meta-analysis

    Recently, there are more and more evidences from studies have revealed the association between microRNA-9 (miR-9) expression and outcome in multiple cancers, but inconsistent results have also been reported. I...

    Yunyuan Zhang, Jun Zhou, Meiling Sun, Guirong Sun… in Pathology & Oncology Research (2017)

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  6. No Access

    Article

    Endogenous level of TIGAR in brain is associated with vulnerability of neurons to ischemic injury

    In previous studies, we showed that TP53-induced glycolysis and apoptosis regulator (TIGAR) protects neurons against ischemic brain injury. In the present study, we investigated the developmental changes of TI...

    Lijuan Cao, Jieyu Chen, Mei Li, Yuan-Yuan Qin, Meiling Sun… in Neuroscience Bulletin (2015)