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  1. No Access

    Article

    Capsaicin functions as a selective degrader of STAT3 to enhance host resistance to viral infection

    Although STAT3 has been reported as a negative regulator of type I interferon (IFN) signaling, the effects of pharmacologically inhibiting STAT3 on innate antiviral immunity are not well known. Capsaicin, appr...

    Mei-qi Zhang, **n Jia, Cui-qin Cheng, Yu-xi Wang, Yi-ying Li… in Acta Pharmacologica Sinica (2023)

  2. No Access

    Article

    Scoparone suppresses mitophagy-mediated NLRP3 inflammasome activation in inflammatory diseases

    Recent evidence shows that targeting NLRP3 inflammasome activation is an important means to treat inflammasome-driven diseases. Scoparone, a natural compound isolated from the Chinese herb Artemisia capillaris Th...

    Wan-di Feng, Yao Wang, Tong Luo, **n Jia, Cui-qin Cheng… in Acta Pharmacologica Sinica (2023)

  3. Article

    Sodium tanshinone IIA sulfonate protects rat myocardium against ischemia-reperfusion injury via activation of PI3K/Akt/FOXO3A/Bim pathway

    To investigate the mechanisms underlying the protective effects of sodium tanshinone IIA sulfonate (STS) in an ischemia-reperfusion (I/R)-induced rat myocardial injury model.

    Mei-qi Zhang, Yue-liang Zheng, Huan Chen, Jian-feng Tu… in Acta Pharmacologica Sinica (2013)

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  4. Article

    Glycyrrhizin protects rat heart against ischemia-reperfusion injury through blockade of HMGB1-dependent phospho-JNK/Bax pathway

    Glycyrrhizin (GL) has been found to inhibit extracellular HMGB1 cytokine's activity, and protect spinal cord, liver and brain against I/R-induced injury in experimental animals. The purpose of this study was t...

    Chang-lin Zhai, Mei-qi Zhang, Yun Zhang, Hong-xia Xu… in Acta Pharmacologica Sinica (2012)

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