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Article
Open AccessAssociation between left ventricular systolic function parameters and myocardial injury, organ failure and mortality in patients with septic shock
Left ventricular ejection fraction (LVEF) is inconsistently associated with poor outcomes in patients with sepsis. Newer parameters such as LV longitudinal strain (LVLS), mitral annular plane systolic excursio...
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Article
Open AccessCombination of serum and peritoneal 1.3-beta-d-glucan can rule out intra-abdominal candidiasis in surgical critically ill patients: a multicenter prospective study
Intra-abdominal candidiasis (IAC) is difficult to predict in critically ill patients with intra-abdominal infection, leading to the overuse of antifungal treatments. Serum and peritoneal 1.3-beta-d-glucan (sBDG a...
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Article
Open AccessInflammation and oxidative stress markers in type 2 diabetes patients with Advanced Carotid atherosclerosis
Type 2 diabetes mellitus (T2DM) is a major global health issue and a significant risk factor for atherosclerosis. Atherosclerosis in T2DM patients has been associated with inflammation, insulin resistance, hyp...
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Article
Open AccessEffect of norepinephrine on the vascular waterfall and tissue perfusion in vasoplegic hypotensive patients: a prospective, observational, applied physiology study in cardiac surgery
Norepinephrine is a commonly used drug for treating vasoplegic acute circulatory failure in ICU. The prediction of norepinephrine macro- and micro-circulatory response is complicated by its uneven receptors’ d...
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Article
Diuretics depletion improves cardiac output and ventriculo-arterial coupling in congestive ICU patients during hemodynamic de-escalation
Purpose: Congestion was shown to hamper organ perfusion, but the exact timing of diuretic initiation during hemodynamic de-escalation in shock is unclear. The aim of this study was to describe the hemodynamic ...
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Open AccessReal life use of vasopressin in patients with cardiogenic shock: a retrospective cohort analysis
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Article
Open AccessPrevalence of systemic venous congestion assessed by Venous Excess Ultrasound Grading System (VExUS) and association with acute kidney injury in a general ICU cohort: a prospective multicentric study
The importance of assessing venous congestion in ICU patients is widely acknowledged, but its study is hampered by the lack of a practical evaluation tool. The Venous Excess Ultrasound Grading System (VExUS), ...
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Article
Open AccessDoppler study of portal vein and renal venous velocity predict the appropriate fluid response to diuretic in ICU: a prospective observational echocardiographic evaluation
Fluid overload and venous congestion are associated with morbi-mortality in the ICU (intensive care unit). Administration of diuretics to correct the fluid balance is common, although there is no strong relati...
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Article
Using the lung ultrasound score to monitor disease progression for COVID-19-associated ARDS
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Article
Are adipokines the missing link between obesity, immune response, and outcomes in severe COVID-19?
Obesity is commonly reported in COVID-19 patients and is associated with poorer outcomes. It is suggested that leptin could be the missing link between obesity and severe COVID-19. Our study aimed to unravel t...
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Article
Open AccessHigh plasma concentration of non-esterified polyunsaturated fatty acids is a specific feature of severe COVID-19 pneumonia
COVID-19 pneumonia has specific features and outcomes that suggests a unique immunopathogenesis. Severe forms of COVID-19 appear to be more frequent in obese patients, but an association with metabolic disorde...
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Article
Open AccessCorrection to: CXCL10 could drive longer duration of mechanical ventilation during COVID-19 ARDS
An amendment to this paper has been published and can be accessed via the original article.
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Article
Open AccessCorrection to: The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome
An amendment to this paper has been published and can be accessed via the original article.
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Article
Open AccessEchocardiographic measure of dynamic arterial elastance predict pressure response during norepinephrine weaning: an observational study
The purpose of this study was to determine whether dynamic elastance EAdyn derived from echocardiographic measurements of stroke volume variations can predict the success of a one-step decrease of norepinephrine ...
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Article
Open AccessPupillometry pain index decreases intraoperative sufentanyl administration in cardiac surgery: a prospective randomized study
Pupillometry has proven effective for the monitoring of intraoperative analgesia in non-cardiac surgery. We performed a prospective randomized study to evaluate the impact of an analgesia-guided pupillometry a...
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Article
Open AccessThe dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome
Although immune modulation is a promising therapeutic avenue in coronavirus disease 2019 (COVID-19), the most relevant targets remain to be found. COVID-19 has peculiar characteristics and outcomes, suggesting...
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Article
Open AccessCXCL10 could drive longer duration of mechanical ventilation during COVID-19 ARDS
COVID-19-related ARDS has unique features when compared with ARDS from other origins, suggesting a distinctive inflammatory pathogenesis. Data regarding the host response within the lung are sparse. The object...
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Article
Oral water ingestion in the treatment of shock patients: a prospective randomized study
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Article
Agreement between different non-invasive methods of ventricular elastance assessment for the monitoring of ventricular–arterial coupling in intensive care
Ventricular–arterial coupling is calculated as the arterial elastance to end systolic elastance ratio (EA/Ees). Although the gold standard is invasive pressure volume loop analysis, Chen method is the clinical re...
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Article
Open AccessEffect of opioid-free anaesthesia on post-operative period in cardiac surgery: a retrospective matched case-control study
No study has been conducted to demonstrate the feasibility of an opioid-free anesthesia (OFA) protocol in cardiac surgery to improve patient care. The aim of the present study was to evaluate the effect of OFA...
