9 Result(s)
within
Maxim Imakaev
Life Sciences
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Article
Open AccessDiverse silent chromatin states modulate genome compartmentalization and loop extrusion barriers
The relationships between chromosomal compartmentalization, chromatin state and function are poorly understood. Here by profiling long-range contact frequencies in HCT116 colon cancer cells, we distinguish thr...
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Article
Open AccessLineage abundance estimation for SARS-CoV-2 in wastewater using transcriptome quantification techniques
Effectively monitoring the spread of SARS-CoV-2 mutants is essential to efforts to counter the ongoing pandemic. Predicting lineage abundance from wastewater, however, is technically challenging. We show that ...
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Article
FISH-ing for captured contacts: towards reconciling FISH and 3C
This Analysis explores the relationship between chromosome conformation capture (for example, Hi-C) and FISH datasets, and uses simulations to reconcile measurements from the two technologies.
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Article
Open AccessGenome-wide transcription start site map** of Bradyrhizobium japonicum grown free-living or in symbiosis – a rich resource to identify new transcripts, proteins and to study gene regulation
Differential RNA-sequencing (dRNA-seq) is indispensable for determination of primary transcriptomes. However, using dRNA-seq data to map transcriptional start sites (TSSs) and promoters genome-wide is a bioinf...
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Article
Open AccessChromosomal architecture changes upon cell differentiation
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Article
Open AccessPolymer models of topological insulators
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Article
Open AccessS cerevisiae genome as a confined equilibrium polymer brush
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Article
Open AccessPolymer models of yeast S. cerevisiae genome organization
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Article
Iterative correction of Hi-C data reveals hallmarks of chromosome organization
ICE (iterative correction and eigenvector decomposition) provides insight into inter- and intrachromosome interaction patterns.
