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Structure of a spliceosome remodelled for exon ligation

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  1. Article

    Open Access

    Data-driven regularization lowers the size barrier of cryo-EM structure determination

    Macromolecular structure determination by electron cryo-microscopy (cryo-EM) is limited by the alignment of noisy images of individual particles. Because smaller particles have weaker signals, alignment errors...

    Dari Kimanius, Kiarash Jamali, Max E. Wilkinson, Sofia Lövestam… in Nature Methods (2024)

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  2. Article

    Open Access

    Internal initiation of reverse transcription in a Penelope-like retrotransposon

    Eukaryotic retroelements are generally divided into two classes: long terminal repeat (LTR) retrotransposons and non-LTR retrotransposons. A third class of eukaryotic retroelement, the Penelope-like elements (...

    Chris J. Frangieh, Max E. Wilkinson, Daniel Strebinger, Jonathan Strecker… in Mobile DNA (2024)

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  3. Article

    Open Access

    Structure of the OMEGA nickase IsrB in complex with ωRNA and target DNA

    RNA-guided systems, such as CRISPR–Cas, combine programmable substrate recognition with enzymatic function, a combination that has been used advantageously to develop powerful molecular technologies1,2. Structura...

    Seiichi Hirano, Kalli Kappel, Han Altae-Tran, Guilhem Faure, Max E. Wilkinson… in Nature (2022)

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