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Article
Open AccessThe potential role of Listeria monocytogenes in promoting colorectal adenocarcinoma tumorigenic process
Listeria monocytogenes is a foodborne pathogen, which can cause a severe illness, especially in people with a weakened immune system or comorbidities. The interactions between host and pathogens and between patho...
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Article
Open AccessA home-based lifestyle intervention program reduces the tumorigenic potential of triple-negative breast cancer cells
Translational research for the evaluation of physical activity habits and lifestyle modifications based on nutrition and exercise has recently gained attention. In this study, we evaluated the effects of serum...
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Article
Open AccessAssociation between metabolic syndrome, insulin resistance, and IGF-1 in breast cancer survivors of DIANA-5 study
Circulating insulin-like growth factor-1 (IGF-1) is positively associated with the risk of BC recurrence, and is more frequently dysregulated in older people, especially in those with metabolic syndrome (MetS)...
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Article
Open AccessMovement and health beyond care, MoviS: study protocol for a randomized clinical trial on nutrition and exercise educational programs for breast cancer survivors
Breast cancer (BC) is the most common invasive cancer in women, and exercise can significantly improve the outcomes of BC survivors. MoviS (Movement and Health Beyond Care) is a randomized controlled trial aim...
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Article
Open AccessMetformin prevents cell tumorigenesis through autophagy-related cell death
Autophagy is a cellular mechanism by which cells degrade intracellular components in lysosomes, maintaining cellular homeostasis. It has been hypothesized that autophagy could have a role in cancer prevention ...
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Article
Open AccessThe intrinsically disordered E-domains regulate the IGF-1 prohormones stability, subcellular localisation and secretion
Insulin-like growth factor-1 (IGF-1) is synthesised as a prohormone (proIGF-1) requiring enzymatic activity to yield the mature IGF-1. Three proIGF-1s are encoded by alternatively spliced IGF-1 mRNAs: proIGF-1...
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Article
Human IGF1 pro-forms induce breast cancer cell proliferation via the IGF1 receptor
IGF1 is a key regulator of tissue growth and development and has been implicated in the initiation and progression of various cancers, including breast cancer. Through IGF1 mRNA splicing different precursor pr...
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Article
Open AccessThe indole-3-carbinol cyclic tetrameric derivative CTet inhibits cell proliferation via overexpression of p21/CDKN1A in both estrogen receptor-positive and triple-negative breast cancer cell lines
Indole-3-carbinol (I3C), an autolysis product of glucosinolates present in cruciferous vegetables, and its dimeric derivative (3,3'-DIM) have been indicated as promising agents in preventing the development an...
