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  1. No Access

    Article

    Recirculating Foxp3+ regulatory T cells are restimulated in the thymus under Aire control

    Thymically-derived Foxp3+ regulatory T cells (Treg) critically control immunological tolerance. These cells are generated in the medulla through high affinity interactions with medullary thymic epithelial cells (...

    Jonathan Charaix, Alexia Borelli… in Cellular and Molecular Life Sciences (2022)

  2. No Access

    Article

    Transcriptional programs that control expression of the autoimmune regulator gene Aire

    Abramson and colleagues show that the coordinated action of several transcriptional regulators, including Irf4, Irf8, Tbx21, Tcf7 and Ctcfl, acts on medullary-thymic-epithelial-cell-specific accessible regions...

    Yonatan Herzig, Shir Nevo, Chamutal Bornstein, Miriam R Brezis… in Nature Immunology (2017)

  3. No Access

    Article

    The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance

    Dysfunction of the deacetylase Sirt1 has been associated with certain metabolic diseases. Abramson and colleagues show that Sirt1 has high expression in the thymus, where it deacetylates the transcriptional re...

    Anna Chuprin, Ayelet Avin, Yael Goldfarb, Yonatan Herzig, Ben Levi… in Nature Immunology (2015)