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Article
Recirculating Foxp3+ regulatory T cells are restimulated in the thymus under Aire control
Thymically-derived Foxp3+ regulatory T cells (Treg) critically control immunological tolerance. These cells are generated in the medulla through high affinity interactions with medullary thymic epithelial cells (...
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Chapter and Conference Paper
Verifiable and Private Oblivious Polynomial Evaluation
It is a challenging problem to delegate the computation of a polynomial on encrypted data to a server in an oblivious and verifiable way. In this paper, we formally define Verifiable and Private Oblivious Polyno...
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Chapter and Conference Paper
Secure and Efficient Matrix Multiplication with MapReduce
MapReduce is one of the most popular distributed programming paradigms that allows processing big data sets in parallel on a cluster. MapReduce users often outsource data and computations to a public cloud, wh...
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Chapter and Conference Paper
No Such Thing as a Small Leak: Leakage-Abuse Attacks Against Symmetric Searchable Encryption
Symmetric Searchable Encryption ( \(\mathrm {SSE}\) ) schemes enable clients to securely outsource their data while maintaining t...
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Chapter and Conference Paper
Secure Joins with MapReduce
MapReduce is one of the most popular programming paradigms that allows a user to process Big data sets. Our goal is to add privacy guarantees to the two standard algorithms of join computation for MapReduce: the
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Chapter
The Autoimmune Regulator (AIRE) Gene, the Master Activator of Self-Antigen Expression in the Thymus
It has been 20 years that the AIRE gene was discovered. It is the causing gene of a rare and life-threatening autoimmune disease with severe manifestations against a variety of organs. Since AIRE’s identification...
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Article
Transcriptional programs that control expression of the autoimmune regulator gene Aire
Abramson and colleagues show that the coordinated action of several transcriptional regulators, including Irf4, Irf8, Tbx21, Tcf7 and Ctcfl, acts on medullary-thymic-epithelial-cell-specific accessible regions...
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Chapter and Conference Paper
Verifiable Private Polynomial Evaluation
Delegating the computation of a polynomial to a server in a verifiable way is challenging. An even more challenging problem is ensuring that this polynomial remains hidden to clients who are able to query such...
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Article
Open AccessExtensive RNA editing and splicing increase immune self-representation diversity in medullary thymic epithelial cells
In order to become functionally competent but harmless mediators of the immune system, T cells undergo a strict educational program in the thymus, where they learn to discriminate between self and non-self. Th...
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Article
The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance
Dysfunction of the deacetylase Sirt1 has been associated with certain metabolic diseases. Abramson and colleagues show that Sirt1 has high expression in the thymus, where it deacetylates the transcriptional re...
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Article
Open AccessIdentification of NF-κB and PLCL2 as new susceptibility genes and highlights on a potential role of IRF8 through interferon signature modulation in systemic sclerosis
Systemic sclerosis (SSc) and primary biliary cirrhosis (PBC) are rare polygenic autoimmune diseases (AIDs) characterized by fibroblast dysfunction. Furthermore, both diseases share some genetic bases with othe...
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Article
An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus
The human thymus is tasked to teach T-cells which antigens are foreign and which are 'self', a process that appears to go wrong in autoimmune disorders. A study of the variation in the promoter of one gene exp...
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Chapter
Original and General Strategy of Dimerization of Bioactive Molecules
Dimerization of an active compound often results in enhanced binding and improved pharmacological properties. This potency is attributed to a higher concentration of pharmacophores in the proximity of recognit...
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Article
Solid phase synthesis of peptidyl aldehydes from C-terminal thiazolidinyl peptides
Peptidyl aldehydes are potent transition state analogue inhibitors of cysteine and serine proteinases. The aldehyde function has recently been used for chemoselective peptide ligation. The preparation of pepti...
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Article
Solid phase synthesis of peptidyl aldehydes from C-terminal thiazolidinyl peptides
Peptidyl aldehydes are potent transition stateanalogue inhibitors of cysteine and serineproteinases. The aldehyde function has recently beenused for chemoselective peptide ligation. Thepreparation of peptidyl ...
