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Article
Chorioamnionitis induces changes in ovine pulmonary endogenous epithelial stem/progenitor cells in utero
Chorioamnionitis, an intrauterine infection of the placenta and fetal membranes, is a common risk factor for adverse pulmonary outcomes in premature infants including BPD, which is characterized by an arrest i...
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Article
Open AccessUreaplasma parvum genotype, combined vaginal colonisation with Candida albicans, and spontaneous preterm birth in an Australian cohort of pregnant women
Detection of Ureaplasma, Mycoplasma and Candida spp. in the vagina during pregnancy has previously been associated with preterm birth (PTB). However, the prevalence of these microorganisms and the associated obst...
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Article
Open AccessIntra-amniotic Candida albicans infection induces mucosal injury and inflammation in the ovine fetal intestine
Chorioamnionitis is caused by intrauterine infection with microorganisms including Candida albicans (C.albicans). Chorioamnionitis is associated with postnatal intestinal pathologies including necrotizing enteroc...
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Article
Open AccessNeuroinflammation and structural injury of the fetal ovine brain following intra-amniotic Candida albicans exposure
Intra-amniotic Candida albicans (C. Albicans) infection is associated with preterm birth and high morbidity and mortality rates. Survivors are prone to adverse neurodevelopmental outcomes. The mechanisms leading ...
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Article
Open AccessDeterminants of mastitis in women in the CASTLE study: a cohort study
Mastitis is an acute, debilitating condition that occurs in approximately 20 % of breastfeeding women who experience a red, painful breast with fever. This paper describes the factors correlated with mastitis ...
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Article
Fluconazole treatment of intrauterine Candida albicans infection in fetal sheep
Intrauterine Candida albicans infection causes severe fetal inflammatory responses and fetal injury in an ovine model. We hypothesized that intra-amniotic antifungal therapy with fluconazole would decrease the ad...
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Article
Open AccessSecond trimester amniotic fluid cytokine concentrations, Ureaplasmasp. colonisation status and sexual activity as predictors of preterm birth in Chinese and Australian women
This study tested if second trimester amniotic fluid cytokine levels, Ureaplasma sp. colonisation and sexual activity predict preterm birth and explain the differential preterm birth rates in Chinese compared to ...
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Article
Intrauterine Candida albicans infection elicits severe inflammation in fetal sheep
Preventing preterm birth and subsequent adverse neonatal sequelae is among the greatest clinical challenges of our time. Recent studies suggest a role for Candida spp. in preterm birth and fetal injury, as a resu...
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Article
Open AccessThe role of micro-organisms (Staphylococcus aureus and Candida albicans) in the pathogenesis of breast pain and infection in lactating women: study protocol
The CASTLE (Candida and Staphylococcus Transmission: Longitudinal Evaluation) study will investigate the micro-organisms involved in the development of mastitis and "breast thrush" among breastfeeding women. T...
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Article
Molecular Microbiological Characterization of Preterm Neonates at Risk of Bronchopulmonary Dysplasia
The role of infection in bronchopulmonary dysplasia (BPD) is unknown. We present an observational study of 55 premature infants born weighing less than 1.3 kg within two level III neonatal intensive care units...
