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Article
A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system
Sustained silencing of gene expression throughout the brain using small interfering RNAs (siRNAs) has not been achieved. Here we describe an siRNA architecture, divalent siRNA (di-siRNA), that supports potent,...
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Article
RNAi modulation of placental sFLT1 for the treatment of preeclampsia
Preeclampsia, a hypertension condition with no approved therapies, is treated in monkeys by gene silencing in the placenta.
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Article
Correction: Corrigendum: Taking charge of siRNA delivery
Nat. Biotechnol. 32, 1197–1198 (2014); published online 9 December 2014; corrected after print 29 April 2015 In the version of this article initially published, in two instances molecules were misidentified in...
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Article
Taking charge of siRNA delivery
Delivery of siRNA into cells is achieved by neutralizing the negative charge of the phosphate backbone in a reversible manner.