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Article
Validation of the Apnealink Air for diagnosis of obstructive sleep apnoea (OSA) in pregnant women in early-mid gestation
The detection of obstructive sleep apnoea (OSA) in pregnant women in early-mid gestation is logistically difficult. Accurate alternates to polysomnography (PSG) in early pregnancy are not well identified. We c...
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Article
Open AccessValidation of self-applied unattended polysomnography using Somte V2 PSG (Somte) for diagnosis of obstructive sleep apnoea (OSA) in pregnant women in early to mid-gestation
Polysomnography (PSG) may be completed in the home environment (unattended), and when self-applied, allow the collection of data with minimal healthcare worker intervention. Self-applied, unattended PSG in the...
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Article
Open AccessA prospective observational cohort study of covid-19 epidemiology and vaccine seroconversion in South Western Sydney, Australia, during the 2021–2022 pandemic period.
It is known that COVID-19 disproportionally adversely affects the immunocompromised, including kidney transplant recipients (KTR), as compared to the general population. Risk factors for adverse outcomes and v...
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Article
Open AccessRemote blood pressure monitoring in high risk pregnancy — study protocol for a randomised controlled trial (REMOTE CONTROL trial)
Pregnant women at high risk for develo** a hypertensive disorder of pregnancy require frequent antenatal assessments, especially of their blood pressure. This expends significant resources for both the patie...
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Article
Open AccessClinical characteristics and sequelae of intrapartum hypertension – a retrospective cohort study
In a significant proportion of pregnant women, elevated blood pressure may first present during the intrapartum period. This phenomenon, intrapartum hypertension, is often overlooked as blood pressure during d...
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Article
Progress in preeclampsia: the contribution of animal models
Recent advances have been made in understanding the nature of placental dysfunction causing preeclampsia, and other hypertensive disorders of pregnancy. The contribution of animal studies in the understanding ...
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Article
Open AccessDiet in the management of non-dialysis dependent chronic kidney disease: perceptions and practices of health professionals
Therapeutic strategies, including dietary intervention, to target non-dialysis dependent Chronic Kidney Disease (CKD) progression have been at the forefront of recent renal research. Nephrologists and other re...
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Article
Open AccessA multi-centre, open label, randomised, parallel-group, superiority Trial to compare the efficacy of URsodeoxycholic acid with RIFampicin in the management of women with severe early onset Intrahepatic Cholestasis of pregnancy: the TURRIFIC randomised trial
Severe early onset (less than 34 weeks gestation) intrahepatic cholestasis of pregnancy (ICP) affects 0.1% of pregnant women in Australia and is associated with a 3-fold increased risk of stillbirth, fetal hyp...
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Article
Galectin-1–Related Modulation of Trophoblast Endothelial Interactions by Integrins α1 and β1
During normal trophoblast invasion, integrins α6β4 are downregulated, and α1β1 are upregulated in invasive cytotrophoblast cells. In preeclampsia both interstitial and endovascular invasion are shallow and cyt...
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Article
Open AccessSerious kidney disease in pregnancy: an Australian national cohort study protocol
Maternal kidney disease (acute kidney injury (AKI), advanced chronic kidney disease (CKD), dependence on dialysis or a kidney transplant) has a substantial impact on pregnancy, with risks of significant perina...
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Article
Aspirin in the prevention of preeclampsia: the conundrum of how, who and when
Aspirin is widely used in preventing early onset preeclampsia in women who are identified as being high risk. Although the benefit of aspirin is increasingly evident and acknowledged, there remains many unansw...
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Article
RNAi modulation of placental sFLT1 for the treatment of preeclampsia
Preeclampsia, a hypertension condition with no approved therapies, is treated in monkeys by gene silencing in the placenta.
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Article
Open AccessVertebral artery dissection in hypertensive disorders of pregnancy: a case series and literature review
Arterial dissection is a rare complication of pregnancy and puerperium. There have been reports of aortic, coronary and cervical artery dissection in association with preeclampsia, however, vertebral artery di...
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Article
Open AccessVariability in mRNA expression of fms-like tyrosine kinase-1 variants in normal and preeclamptic placenta
Preeclampsia is a complication of pregnancy characterised by gestational hypertension and proteinuria and is a leading cause of morbidity and mortality in both mothers and infants. Certain anti-angiogenic fact...
