-
Article
Integrative regulation of physiology by histone deacetylase 3
Cell-type-specific gene expression is physiologically modulated by the binding of transcription factors to genomic enhancer sequences, to which chromatin modifiers such as histone deacetylases (HDACs) are recr...
-
Article
Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge
Histone deacetylase 3 (HDAC3) is required to activate brown adipose tissue enhancers to ensure thermogenic aptitude.
-
Article
The role of mouse Akt2 in insulin-dependent suppression of adipocyte lipolysis in vivo
The release of fatty acids from adipocytes, i.e. lipolysis, is maintained under tight control, primarily by the opposing actions of catecholamines and insulin. A widely accepted model is that insulin antagonis...
-
Article
The nuclear receptor Rev-erbα controls circadian thermogenic plasticity
The nuclear receptor Rev-erbα, a powerful repressor of transcription, is shown to link circadian and thermogenic networks by regulating the function of brown adipose tissue.
