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Article
Antiviral CD8+ T cells cause an experimental autoimmune encephalomyelitis-like disease in naive mice
Major histocompatibility complex class I-restricted CD8+ cytotoxic T lymphocytes are involved in the pathogenesis of multiple sclerosis (MS) and both autoimmune, experimental autoimmune encephalomyelitis, and vir...
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Article
Molecular Mimicry as a Mechanism of Autoimmune Disease
A variety of mechanisms have been suggested as the means by which infections can initiate and/or exacerbate autoimmune diseases. One mechanism is molecular mimicry, where a foreign antigen shares sequence or s...
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Article
The role of peripheral interleukin-6 in the development of acute seizures following virus encephalitis
Seizure disorders are often associated with infectious etiologies. Infection, via the intracerebral (i.c.) route, of C57BL/6J mice with the Daniels (DA) strain of Theiler’s murine encephalomyelitis virus (TMEV...
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Article
Open AccessClass II HLA-DRB4 is a predictive biomarker for survival following immunotherapy in metastatic non-small cell lung cancer
Immune checkpoint inhibitors (ICI) are important treatment options for metastatic non-small cell lung cancer (mNSCLC). However, not all patients benefit from ICIs and can experience immune-related adverse even...