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  1. No Access

    Article

    Analysis of the HEXA, HEXB, ARSA, and SMPD1 Genes in 68 Iranian Patients

    Lysosomal storage diseases (LSDs) are known as genetic disorders with an overall prevalence of 1 per 7700 live births. Sphingolipidosis, which is a subgroup of LSDs, is resulted from mutations in the coding ge...

    Rezvan Abtahi, Parvaneh Karimzadeh, Alireza Rezayi… in Journal of Molecular Neuroscience (2022)

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    Article

    A Novel Mitochondrial Heteroplasmic C13806A Point Mutation Associated with Iranian Friedreich’s Ataxia

    Friedreich’s ataxia (FRDA) is an autosomal recessive neurodegenerative disorder caused by decreased expression of the protein Frataxin. Frataxin deficiency leads to excessive free radical production and dysfun...

    Mohammad Mehdi Heidari, Massoud Houshmand… in Cellular and Molecular Neurobiology (2009)

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    Article

    Analysis of HLA DR2&DQ6 (DRB1*1501, DQA1*0102, DQB1*0602) Haplotypes in Iranian Patients with Multiple Sclerosis

    Multiple sclerosis (MS) is prototype of inflammatory demyelinating disease of the central nervous system .The etiology of MS remains unclear, but according to current data the disease develops in genetically s...

    Mojdeh Ghabaee, Asghar Bayati… in Cellular and Molecular Neurobiology (2009)

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    Article

    Investigation of tRNALeu/Lys and ATPase 6 Genes Mutations in Huntington’s Disease

    Huntington disease (HD) is a genetically dominant condition caused by expanded CAG repeats which code for glutamine in the HD gene product, huntingtin. Huntingtin is expressed in almost all tissues, so abnorma...

    Sadaf Kasraie, Massoud Houshmand… in Cellular and Molecular Neurobiology (2008)

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    Article

    Huntington’s Disease and Mitochondrial DNA Deletions: Event or Regular Mechanism for Mutant Huntingtin Protein and CAG Repeats Expansion?!

    The mitochondrial DNA (mtDNA) may play an essential role in the pathogenesis of the respiratory chain complex activities in neurodegenerative disorders such as Huntington’s disease (HD). Research studies were ...

    Mohammad Mehdi Banoei, Massoud Houshmand… in Cellular and Molecular Neurobiology (2007)

  6. No Access

    Article

    Investigation on Mitochondrial tRNALeu/Lys, NDI and ATPase 6/8 in Iranian Multiple Sclerosis Patients

    As with chromosomal DNA, the mitochondrial DNA (mtDNA) can contain mutations that are highly pathogenic .In fact, many diseases of the central nervous system are known to be caused by mutations in mtDNA. Dysfu...

    Solmaz Etemad Ahari, Massoud Houshmand… in Cellular and Molecular Neurobiology (2007)

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    Article

    Do Haplogroups H and U Act to Increase the Penetrance of Alzheimer’s Disease?

    1. Alzheimer’s disease (AD) is the most common form of dementia in the elderly in which interplay between genes and the environment is supposed to be involved. Mitochondrial DNA (mtDNA) has the only noncoding ...

    Farzaneh Fesahat, Massoud Houshmand… in Cellular and Molecular Neurobiology (2007)

  8. No Access

    Article

    Mitochondrial D-Loop Variation in Persian Multiple Sclerosis Patients: K and A Haplogroups as a Risk Factor!!

    Multiple Sclerosis (MS) is a multifocal demyelinating central nervous system disorder in which interplay between genes and the environment are supposed to be involved. Mitochondrial DNA (mtDNA) has the only no...

    Hassan Hassani- Kumleh, Massoud Houshmand… in Cellular and Molecular Neurobiology (2006)