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Article
Open AccessSIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice
Brown adipose tissue plays a central role in the regulation of the energy balance by expending energy to produce heat. NAD+-dependent deacylase sirtuins have widely been recognized as positive regulators of brown...
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Article
Open AccessGenome editing using a versatile vector-based CRISPR/Cas9 system in Fusarium species
Fusarium species include important filamentous fungal pathogens that can infect plants, animals, and humans. Meanwhile, some nonpathogenic Fusarium species are promising biocontrol agents against plant pathogens....
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Article
Open AccessThree-dimensional culture models mimic colon cancer heterogeneity induced by different microenvironments
Colorectal cancer demonstrates intra-tumour heterogeneity formed by a hierarchical structure comprised of cancer stem cells (CSCs) and their differentiated progenies. The mechanism by which CSCs are maintained...