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  1. Article

    Open Access

    SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice

    Brown adipose tissue plays a central role in the regulation of the energy balance by expending energy to produce heat. NAD+-dependent deacylase sirtuins have widely been recognized as positive regulators of brown...

    Tatsuya Yoshizawa, Yoshifumi Sato, Shihab U. Sobuz in Nature Communications (2022)

  2. Article

    Open Access

    Genome editing using a versatile vector-based CRISPR/Cas9 system in Fusarium species

    Fusarium species include important filamentous fungal pathogens that can infect plants, animals, and humans. Meanwhile, some nonpathogenic Fusarium species are promising biocontrol agents against plant pathogens....

    Sota Shinkado, Hiroki Saito, Masaya Yamazaki, Shunsuke Kotera in Scientific Reports (2022)

  3. Article

    Open Access

    Three-dimensional culture models mimic colon cancer heterogeneity induced by different microenvironments

    Colorectal cancer demonstrates intra-tumour heterogeneity formed by a hierarchical structure comprised of cancer stem cells (CSCs) and their differentiated progenies. The mechanism by which CSCs are maintained...

    Shigeto Kawai, Masaki Yamazaki, Keita Shibuya, Masaya Yamazaki in Scientific Reports (2020)