43 Result(s)
within
Masanori Kasahara
Immunology
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Article
Prof. Dr. Jan Klein (1936-2023)
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Article
The immune system of jawless vertebrates: insights into the prototype of the adaptive immune system
Jawless vertebrates diverged from an ancestor of jawed vertebrates approximately 550 million years ago. They mount adaptive immune responses to repetitive antigenic challenges, despite lacking major histocompa...
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Article
Biology, evolution, and history of antigen processing and presentation: Immunogenetics special issue 2019
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Article
Origin and evolution of the specialized forms of proteasomes involved in antigen presentation
Proteasomes are a multi-subunit protease complex that produces peptides bound by major histocompatibility complex (MHC) class I molecules. Phylogenetic studies indicate that two specialized forms of proteasome...
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Article
The immunoproteasome and thymoproteasome: functions, evolution and human disease
The basic principle of adaptive immunity is to strictly discriminate between self and non-self, and a central challenge to overcome is the enormous variety of pathogens that might be encountered. In cell-media...
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Article
Open AccessDouble-stranded RNA analog and type I interferon regulate expression of Trem paired receptors in murine myeloid cells
Triggering receptors expressed on myeloid cells (Trem) proteins are a family of cell surface receptors used to control innate immune responses such as proinflammatory cytokine production in mice. Trem genes be...
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Chapter
Anchorage-Dependent Multicellular Aggregate Formation Induces CD44 High Cancer Stem Cell-Like Phenotypes in Adult T Cell Leukemia/Lymphoma Cells
Adult T cell leukemia/lymphoma (ATL) is a highly invasive and intractable T cell malignancy caused by human T cell leukemia virus-1 infection. Leukemia/lymphoma cells that have invaded the tissues exhibit a pr...
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Chapter
Variable Lymphocyte Receptors: A Current Overview
Jawless vertebrates represented by lampreys and hagfish mount antigen-specific immune responses using variable lymphocyte receptors. These receptors generate diversity comparable to that of T-cell and B-cell r...
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Article
Copy number and sequence variation of leucine-rich repeat modules suggests distinct functional constraints operating on variable lymphocyte receptors expressed by agnathan T cell-like and B cell-like lymphocytes
Unlike jawed vertebrates that use T cell and B cell receptors for antigen recognition, jawless vertebrates represented by lampreys and hagfish use variable lymphocyte receptors (VLR) as antigen receptors. VLRs...
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Article
Thymoproteasome: Role in Thymic Selection and Clinical Significance as a Diagnostic Marker for Thymic Epithelial Tumors
The thymoproteasome is a specialized type of proteasomes expressed exclusively in the thymic cortex. It has a unique catalytic subunit β5t with unusual enzymatic activity. The thymoproteasome exhibits lower ch...
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Article
Immunogenetics of the NKG2D ligand gene family
NKG2D ligands (NKG2DLs) are a group of major histocompatibility complex (MHC) class I-like molecules, the expression of which is induced by cellular stresses such as infection, tumorigenesis, heat shock, tissu...
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Article
Comparative genomic analysis of the proteasome β5t subunit gene: implications for the origin and evolution of thymoproteasomes
The thymoproteasome is a recently discovered, specialized form of 20S proteasomes expressed exclusively in the thymic cortex. Although the precise molecular mechanism by which the thymoproteasome exerts its fu...
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Erratum to: Comparative genomic analysis of mammalian NKG2D ligand family genes provides insights into their origin and evolution
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Article
Erratum to: Comparative genomic analysis of mammalian NKG2D ligand family genes provides insights into their origin and evolution
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Article
Comparative genomic analysis of mammalian NKG2D ligand family genes provides insights into their origin and evolution
NKG2D is a major activating receptor of natural killer cells. Its ligands are major histocompatibility complex (MHC) class I-like molecules whose expression is induced by cellular stresses such as infections a...
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Article
Two variable lymphocyte receptor genes of the inshore hagfish are located far apart on the same chromosome
Variable lymphocyte receptors (VLR) generate enormous diversity through assembling highly diverse leucine-rich repeat (LRR) modules and presumably function as antigen receptors in jawless vertebrates. The hagf...
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Article
Variable domains in hagfish: NICIR is a polymorphic multigene family expressed preferentially in leukocytes and is related to lamprey TCR-like
The jawless vertebrates, represented by hagfish and lampreys, are the most advanced animals that apparently lack T cell and B cell receptors. As such, they offer unique opportunities for understanding the evol...
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Article
Chicken CD1 genes are located in the MHC: CD1 and endothelial protein C receptor genes constitute a distinct subfamily of class-I-like genes that predates the emergence of mammals
Mammals have several major histocompatibility complex (MHC) class-I-like genes. Although some of them are assumed to have originated before the emergence of mammals, the origin of class-I-like genes is poorly ...
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Article
Identification of the rat IgA Fc receptor encoded in the leukocyte receptor complex
Human FcαRI (CD89) is a myeloid-specific IgA Fc receptor encoded in the leukocyte receptor complex. Thus far, no gene coding for FcαRI has been identified in mice. Here, we show that, unlike mice, rats have th...
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Article
Genomic analysis of immunity in a Urochordate and the emergence of the vertebrate immune system: “waiting for Godot”
Genome-wide sequence analysis in the invertebrate chordate, Ciona intestinalis, has provided a comprehensive picture of immune-related genes in an organism that occupies a key phylogenetic position in vertebrate ...
