34 Result(s)

Article

The immune system of jawless vertebrates: insights into the prototype of the adaptive immune system

Jawless vertebrates diverged from an ancestor of jawed vertebrates approximately 550 million years ago. They mount adaptive immune responses to repetitive antigenic challenges, despite lacking major histocompa...

Yoichi Sutoh, Masanori Kasahara in Immunogenetics (2021)

Article

Origin and evolution of the specialized forms of proteasomes involved in antigen presentation

Proteasomes are a multi-subunit protease complex that produces peptides bound by major histocompatibility complex (MHC) class I molecules. Phylogenetic studies indicate that two specialized forms of proteasome...

Masanori Kasahara, Martin F. Flajnik in Immunogenetics (2019)

Article

Copy number and sequence variation of leucine-rich repeat modules suggests distinct functional constraints operating on variable lymphocyte receptors expressed by agnathan T cell-like and B cell-like lymphocytes

Unlike jawed vertebrates that use T cell and B cell receptors for antigen recognition, jawless vertebrates represented by lampreys and hagfish use variable lymphocyte receptors (VLR) as antigen receptors. VLRs...

Yoichi Sutoh, Masanori Kasahara in Immunogenetics (2014)

Article

Immunogenetics of the NKG2D ligand gene family

NKG2D ligands (NKG2DLs) are a group of major histocompatibility complex (MHC) class I-like molecules, the expression of which is induced by cellular stresses such as infection, tumorigenesis, heat shock, tissu...

Masanori Kasahara, Shigeru Yoshida in Immunogenetics (2012)

Article

Comparative genomic analysis of the proteasome β5t subunit gene: implications for the origin and evolution of thymoproteasomes

The thymoproteasome is a recently discovered, specialized form of 20S proteasomes expressed exclusively in the thymic cortex. Although the precise molecular mechanism by which the thymoproteasome exerts its fu...

Yoichi Sutoh, Mizuho Kondo, Yuko Ohta, Tatsuya Ota, Utano Tomaru… in Immunogenetics (2012)

Article

Comparative genomic analysis of mammalian NKG2D ligand family genes provides insights into their origin and evolution

NKG2D is a major activating receptor of natural killer cells. Its ligands are major histocompatibility complex (MHC) class I-like molecules whose expression is induced by cellular stresses such as infections a...

Mizuho Kondo, Takako Maruoka, Noriyuki Otsuka, Jun Kasamatsu… in Immunogenetics (2010)

Article

Two variable lymphocyte receptor genes of the inshore hagfish are located far apart on the same chromosome

Variable lymphocyte receptors (VLR) generate enormous diversity through assembling highly diverse leucine-rich repeat (LRR) modules and presumably function as antigen receptors in jawless vertebrates. The hagf...

Jun Kasamatsu, Takashi Suzuki, Junko Ishijima, Yoichi Matsuda… in Immunogenetics (2007)

Article

Variable domains in hagfish: NICIR is a polymorphic multigene family expressed preferentially in leukocytes and is related to lamprey TCR-like

The jawless vertebrates, represented by hagfish and lampreys, are the most advanced animals that apparently lack T cell and B cell receptors. As such, they offer unique opportunities for understanding the evol...

Chiaki Haruta, Takashi Suzuki, Masanori Kasahara in Immunogenetics (2006)

Article

Chicken CD1 genes are located in the MHC: CD1 and endothelial protein C receptor genes constitute a distinct subfamily of class-I-like genes that predates the emergence of mammals

Mammals have several major histocompatibility complex (MHC) class-I-like genes. Although some of them are assumed to have originated before the emergence of mammals, the origin of class-I-like genes is poorly ...

Takako Maruoka, Hideyuki Tanabe, Marin Chiba, Masanori Kasahara in Immunogenetics (2005)

Article

Identification of the rat IgA Fc receptor encoded in the leukocyte receptor complex

Human FcαRI (CD89) is a myeloid-specific IgA Fc receptor encoded in the leukocyte receptor complex. Thus far, no gene coding for FcαRI has been identified in mice. Here, we show that, unlike mice, rats have th...

Takako Maruoka, Taeko Nagata, Masanori Kasahara in Immunogenetics (2004)

Article

Genomic analysis of immunity in a Urochordate and the emergence of the vertebrate immune system: “waiting for Godot”

Genome-wide sequence analysis in the invertebrate chordate, Ciona intestinalis, has provided a comprehensive picture of immune-related genes in an organism that occupies a key phylogenetic position in vertebrate ...

Kaoru Azumi, Rosaria De Santis, Anthony De Tomaso, Isidore Rigoutsos… in Immunogenetics (2003)

Article

Identification of the mouse killer immunoglobulin-like receptor-like (Kirl) gene family map** to Chromosome X

Natural killer (NK) inhibitory receptors, which recognize major histocompatability complex (MHC) proteins in humans, are known as killer Ig-like receptors (KIRs) and are encoded by a multi-gene immunoglobulin ...

Alice Y. Welch, Masanori Kasahara, Lisa M. Spain in Immunogenetics (2003)

Article

The leukocyte common antigen (CD45) of the Pacific hagfish, Eptatretus stoutii: implications for the primordial function of CD45

CD45, originally known as the leukocyte common antigen, is a prototypical transmembrane protein tyrosine phosphatase that plays a critical role in signal transduction through T-cell and B-cell receptors, as w...

Taeko Nagata, Takashi Suzuki, Yuko Ohta, Martin F. Flajnik… in Immunogenetics (2002)

Article

Changes

Ronald E. Bontrop, Masanori Kasahara in Immunogenetics (2001)

Article

Nucleotide sequence analysis of the ~35-kb segment containing interferon-γ-inducible mouse proteasome activator genes

The proteasome activator PA28 is an interferon-γ-inducible complex made up of two related subunits, named PA28α and PA28β, with approximately 50% amino acid sequence identity. Accumulated evidence indicates t...

Makoto Yawata, Shigeo Murata, Keiji Tanaka, Yoshiaki Ishigatsubo… in Immunogenetics (2001)

Article

Gene arrangement of the killer cell inhibitory receptor family on human chromosome 19q13.4 detected by fiber-FISH

 Human chromosome 19q13.4 has recently been revealed to be a remarkable region harboring multiple receptor genes of the immunoglobulin (Ig) superfamily differentially expressed on hematopoietic cell lineages. ...

Y. Suto, Yoshihide Ishikawa, Masanori Kasahara, Fumio Kasai, Toshio Yabe… in Immunogenetics (1998)