11 Result(s)

Article

Author Correction: TriQuinoline

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Shinya Adachi, Masakatsu Shibasaki, Naoya Kumagai in Nature Communications (2020)

Article

TriQuinoline

The bottom-up synthesis of structurally well-defined motifs of graphitic materials is crucial to understanding their physicochemical properties and to elicit new functions. Herein, we report the design and syn...

Shinya Adachi, Masakatsu Shibasaki, Naoya Kumagai in Nature Communications (2019)

Article

Anti-influenza virus activity of a salcomine derivative mediated by inhibition of viral RNA synthesis

Influenza virus infection is a major threat to global health. Although vaccines and anti-influenza virus drugs are available, annual influenza virus epidemics result in severe illness, and an influenza pandemi...

Naoki Takizawa, Tomoyuki Kimura, Takumi Watanabe… in Archives of Virology (2018)

Article

Discovery of 2-hydroxyarbekacin, a new aminoglycoside antibiotic with reduced nephrotoxicity

Yoshiaki Takahashi, Eijiro Umemura, Yoshihiko Kobayashi… in The Journal of Antibiotics (2018)

Article

Memory of Professor Hamao Umezawa

Masakatsu Shibasaki, Katsuhisa Yamazaki in The Journal of Antibiotics (2018)

Article

Biological activity of intervenolin analogs with a phenyl substituent

Intervenolin analogs with a phenyl substituent at the 2- or 3-position were synthesized. The compounds (3–11) showed weak or no inhibitory activity toward the growth of MKN-74 gastric adenocarcinoma cells, even i...

Hikaru Abe, Manabu Kawada, Masayuki Igarashi, Shun-ichi Ohba… in The Journal of Antibiotics (2018)

Article

A guanine derivative as a new MEK inhibitor produced by Streptomyces sp. MK63-43F2

Mitogen-activated protein kinase (MAPK) pathways that direct cellular responses are involved in various biological processes; the RAS-RAF-MEK-ERK pathway is one of the most important MAPK pathways. It is frequ...

Masatomi Iijima, Yuji Kubota, Ryuichi Sawa, Yumiko Kubota… in The Journal of Antibiotics (2018)

Article

Synthetic studies of viridiofungins, broad-spectrum antifungal agents and serine palmitoyl transferase inhibitors

Viridiofungins are alkyl citrate natural products characterized by their inhibitory effects on squalene synthase and serine palmitoyl transferase. Their activities as broad-spectrum antifungal agents as well a...

Naoya Kumagai, Masakatsu Shibasaki in The Journal of Antibiotics (2018)

Article

Acremopeptin, a new peptaibol from Acremonium sp. PF1450

Masatomi Iijima, Masahide Amemiya, Ryuichi Sawa… in The Journal of Antibiotics (2017)

Article

New anti-cancer chemicals Ertredin and its derivatives, regulate oxidative phosphorylation and glycolysis and suppress sphere formation in vitro and tumor growth in EGFRvIII-transformed cells

EGFRvIII is a mutant form of the epidermal growth factor receptor gene (EGFR) that lacks exons 2–7. The resulting protein does not bind to ligands and is constitutively activated. The expression of EGFRvIII is li...

Sonoko Atsumi, Chisato Nosaka, Hayamitsu Adachi, Tomoyuki Kimura… in BMC Cancer (2016)

Article

Coccoquinones A and B, new anthraquinone derivatives produced by Staphylotrichum coccosporum PF1460

Daisuke Tatsuda, Masahide Amemiya, Ryuichi Sawa… in The Journal of Antibiotics (2016)