Chembiomolecular Science
At the Frontier of Chemistry and Biology
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Masakatsu Shibasaki
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Article
Open AccessAuthor Correction: TriQuinoline
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessTriQuinoline
The bottom-up synthesis of structurally well-defined motifs of graphitic materials is crucial to understanding their physicochemical properties and to elicit new functions. Herein, we report the design and syn...
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Chapter
Asymmetric Synthesis Using Thioamides
Following the preceding chapter in which synthesis and transformation of thioamides were introduced, this chapter provides an overview of state-of-the-art asymmetric catalysis to elicit the hidden reactivity o...
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Article
Anti-influenza virus activity of a salcomine derivative mediated by inhibition of viral RNA synthesis
Influenza virus infection is a major threat to global health. Although vaccines and anti-influenza virus drugs are available, annual influenza virus epidemics result in severe illness, and an influenza pandemi...
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Article
Discovery of 2-hydroxyarbekacin, a new aminoglycoside antibiotic with reduced nephrotoxicity
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Article
Memory of Professor Hamao Umezawa
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Article
Biological activity of intervenolin analogs with a phenyl substituent
Intervenolin analogs with a phenyl substituent at the 2- or 3-position were synthesized. The compounds (3–11) showed weak or no inhibitory activity toward the growth of MKN-74 gastric adenocarcinoma cells, even i...
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Chapter
Interplay of Diamides and Rare Earth Metals: Specific Molecular Spaces and Catalytic Activity
A catalytic system comprising functionalized small diamides and rare earth metals (REs) exerts intriguing catalytic properties that are dictated by dynamic construction of flexible molecular spaces. The dynami...
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Article
A guanine derivative as a new MEK inhibitor produced by Streptomyces sp. MK63-43F2
Mitogen-activated protein kinase (MAPK) pathways that direct cellular responses are involved in various biological processes; the RAS-RAF-MEK-ERK pathway is one of the most important MAPK pathways. It is frequ...
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Article
Synthetic studies of viridiofungins, broad-spectrum antifungal agents and serine palmitoyl transferase inhibitors
Viridiofungins are alkyl citrate natural products characterized by their inhibitory effects on squalene synthase and serine palmitoyl transferase. Their activities as broad-spectrum antifungal agents as well a...
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Chapter
Chiral Bimetallic Lewis Acids
Here, we review the utility of chiral bimetallic (multimetallic) Lewis acidic complexes in catalytic asymmetric transformations. Bimetallic complexes are endowed with dual catalytic functions that synergistica...
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Article
Acremopeptin, a new peptaibol from Acremonium sp. PF1450
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Article
Unique physicochemical and catalytic properties dictated by the B3NO2 ring system
The expansion of molecular diversity beyond what nature can produce is a fundamental objective in chemical sciences. Despite the rich chemistry of boron-containing heterocycles, the 1,3-dioxa-5-aza-2,4,6-tribo...
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Chapter
Recent Advances in Rare Earth Metal Asymmetric Catalysis Toward Practical Synthesis of Therapeutics
Two case studies regarding the development of rare earth metal-based asymmetric catalysts are summarized, with particular focus on the process of refining catalysts amenable to industrial applications. Amide-b...
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Article
Open AccessNew anti-cancer chemicals Ertredin and its derivatives, regulate oxidative phosphorylation and glycolysis and suppress sphere formation in vitro and tumor growth in EGFRvIII-transformed cells
EGFRvIII is a mutant form of the epidermal growth factor receptor gene (EGFR) that lacks exons 2–7. The resulting protein does not bind to ligands and is constitutively activated. The expression of EGFRvIII is li...
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Article
Coccoquinones A and B, new anthraquinone derivatives produced by Staphylotrichum coccosporum PF1460
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Book and Conference Proceedings
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Chapter and Conference Paper
Practical Catalytic Asymmetric Synthesis of a Promising Drug Candidate
Cellular glucose is mostly metabolized by the glycolytic pathway in vivo, and only a small amount of nonphosphorylated glucose enters into the polyol pathway, an alternative route of glucose metabolism [1]. Th...
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Chapter
Cationic Bismuth-Catalyzed Hydroamination and Direct Substitution of the Hydroxy Group in Alcohols with Amides
Bismuth-catalyzed hydroamination and direct substitution of the hydroxy group in alcohols are described in this chapter. Intermolecular 1:1 hydroamination of 1,3-dienes with carbamates, sulfonamides, and carbo...
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Book
