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Article
Open AccessPeripheral CD4 memory T cells predict the efficacy of immune checkpoint inhibitor therapy in patients with non-small cell lung cancer
Immune checkpoint inhibitors have significantly improved the prognosis in patients with non-small cell lung cancer, compared with cytotoxic agents. However, the prediction of treatment response is often diffic...
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Article
Open AccessImpact of sequential therapy with osimertinib on the overall survival in patients with EGFR-mutant non-small cell lung cancer
We conducted a retrospective analysis of the data of patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) to investigate the associations between clinical factors and...
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Article
Open AccessLong-Term Safety and Efficacy of Blonanserin Transdermal Patches in Japanese Patients with Schizophrenia: A 52-Week Open-Label, Multicenter Study
Blonanserin transdermal patch therapy is now available in Japan for the treatment of schizophrenia and may provide several advantages over the tablet formulation.
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Article
Open AccessiFISH is a publically available resource enabling versatile DNA FISH to study genome architecture
DNA fluorescence in situ hybridization (DNA FISH) is a powerful method to study chromosomal organization in single cells. At present, there is a lack of free resources of DNA FISH probes and probe design tools...
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Article
A case of bleeding duodenal ulcer with pemphigus vulgaris during steroid therapy
We report a rare case of bleeding duodenal ulceration in the different form of pemphigus vulgaris (PV). A 52-year-old female was diagnosed with acute pharyngitis and administered methylprednisolone. After seve...
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Article
Open AccessDuration of androgen deprivation therapy with maximum androgen blockade for localized prostate cancer
Primary androgen deprivation therapy (ADT) is a treatment option not only for advanced but also for localized prostate cancer. However, the appropriate duration for primary ADT for localized prostate cancer ha...
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Article
Abstracts for the 6th Congress of Asian Sleep Research Society
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Article
Open AccessRelation between psychosocial variables and the glycemic control of patients with type 2 diabetes: A cross-sectional and prospective study
This cross-sectional and prospective study used a variety of psychological inventories to evaluate the relationship between psychosocial factors and the glycemic control of patients with type 2 diabetes.
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Article
Gastric emptying in diabetic patients by the 13C-octanoic acid breath test: role of insulin in gastric motility
Impairment of gastric emptying is well recognized in patients with diabetes mellitus (DM), especially long-standing insulin-dependent diabetes mellitus (IDDM). The aim of this study was to evaluate the cause o...
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Article
Interactions among ammonia fungi on MY agar medium with varying pH
Five early-phase ammonia fungi (EP fungi) – Amblyosporium botrytis, Ascobolus denudatus, Peziza moravecii, Pseudombrophila petrakii, Coprinopsis phlyctidospora, and Tephrocybe tesquorum, and one late-phase ammoni...
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Article
Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13–p12 in Japanese
Type 2 diabetes mellitus is a heterogeneous disorder, and the development of type 2 diabetes mellitus is associated with both insulin secretion defect and insulin resistance. The primary metabolic defect leadi...
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Article
NSAID-induced small intestinal damage: role of COX inhibition
Indomethacin, the nonselective COX inhibitor, decreased mucosal PGE2 content and caused damage in the intestine within 24 h, accompanied by increase in intestinal motility, bacterial number and MPO, as well as iN...
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Article
Clinical study on the ratio of glucose/fat in peripheral parenteral nutrition and the usage of a midline catheter
Two important unsolved questions related to peripheral parenteral nutrition are the ratio of components in the intravenous (IV) solution and catheter-related complications. The present study was undertaken to ...
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Article
Effects of intraduodenal administration of a low dose of cholecystokinin (CCK) antagonist (CR-1505) on plasma CCK concentration, intestinal CCK content, and levels of CCK mRNA
The effects of the intraduodenal administration of a low dose of CR-1505 for 3–7 days on the gene expression of cholecystokinin (CCK), plasma CCK concentration, and CCK content in the intestinal mucosa were ex...
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Article
Endoscopic injection sclerotherapy for esophageal variceal hemorrhage in myeloproliferative disorder: Case report
A 7-year-old woman with myeloproliferative disorder and massive splenomegaly presented with hematemesis. Emergency endoscopy demonstrated bleeding from esophageal varices. Management of variceal hemorrhage by ...
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Enhanced Expression of the c-myc Oncogenes in Human Brain Tumors
Recent advances in molecular biology have provided evidence that the pathological expression of the oncogene is related to cell transformation in vitro and malignancy in vivo [1]. Several oncogenes are activat...
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Article
Treatment of chronic hepatitis B with recombinant leukocyte interferon and cyanidanol
Twelve male patients with chronic hepatitis B were treated by the combination of recombinant human α-interferon and cyanidanol. They received 3 million units of interferon twice a week and 2,250 mg of cyanidan...
