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  1. Article

    Open Access

    Tumoricidal efficacy coincides with CD11c up-regulation in antigen-specific CD8+ T cells during vaccine immunotherapy

    Dendritic cells (DCs) mount tumor-associated antigens (TAAs), and the double-stranded RNA adjuvant Poly(I:C) stimulates Toll-like receptor 3 (TLR3) signal in DC, which in turn induces type I interferon (IFN) a...

    Yohei Takeda, Masahiro Azuma… in Journal of Experimental & Clinical Cancer … (2016)

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  2. Article

    Open Access

    Double-stranded RNA analog and type I interferon regulate expression of Trem paired receptors in murine myeloid cells

    Triggering receptors expressed on myeloid cells (Trem) proteins are a family of cell surface receptors used to control innate immune responses such as proinflammatory cytokine production in mice. Trem genes be...

    Jun Kasamatsu, Mengyao Deng, Masahiro Azuma, Kenji Funami, Hiroaki Shime… in BMC Immunology (2016)

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  3. No Access

    Chapter

    Pattern Recognition by Dendritic Cells and Its Application to Vaccine Adjuvant for Antitumor Immunotherapy

    Dendritic cells (DCs) initiate the maturation to a specific stage in response to stimuli with microbial pattern molecules (PAMP) and trigger activation of host immune response together with antigens (Ags). Rec...

    Tsukasa Seya, Masahiro Azuma, Misako Matsumoto in Immunotherapy of Cancer (2016)

  4. No Access

    Chapter

    Adjuvant Immunotherapy for Cancer: From Basic Research to Clinical Bench

    Microbial infection is usually accompanied by inflammation and tissue wounding. These local symptoms are dependent on a host’s immune response rather than the direct cell damage by invading microbes. A microbe...

    Misako Matsumoto, Masahiro Azuma, Tsukasa Seya in Inflammation and Immunity in Cancer (2015)