![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Open AccessTumoricidal efficacy coincides with CD11c up-regulation in antigen-specific CD8+ T cells during vaccine immunotherapy
Dendritic cells (DCs) mount tumor-associated antigens (TAAs), and the double-stranded RNA adjuvant Poly(I:C) stimulates Toll-like receptor 3 (TLR3) signal in DC, which in turn induces type I interferon (IFN) a...
-
Article
Open AccessDouble-stranded RNA analog and type I interferon regulate expression of Trem paired receptors in murine myeloid cells
Triggering receptors expressed on myeloid cells (Trem) proteins are a family of cell surface receptors used to control innate immune responses such as proinflammatory cytokine production in mice. Trem genes be...
-
Chapter
Pattern Recognition by Dendritic Cells and Its Application to Vaccine Adjuvant for Antitumor Immunotherapy
Dendritic cells (DCs) initiate the maturation to a specific stage in response to stimuli with microbial pattern molecules (PAMP) and trigger activation of host immune response together with antigens (Ags). Rec...
-
Article
Defined TLR3-specific adjuvant that induces NK and CTL activation without significant cytokine production in vivo
Ligand stimulation of the Toll-like receptors (TLRs) triggers innate immune response, cytokine production and cellular immune activation in dendritic cells. However, most TLR ligands are microbial constituents...
-
Chapter
Adjuvant Immunotherapy for Cancer: From Basic Research to Clinical Bench
Microbial infection is usually accompanied by inflammation and tissue wounding. These local symptoms are dependent on a host’s immune response rather than the direct cell damage by invading microbes. A microbe...