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Article
Open AccessPKC regulates αKlotho gene expression in MDCK and NRK-52E cells
Particularly expressed in the kidney, αKlotho is a transmembrane protein that acts together with bone hormone fibroblast growth factor 23 (FGF23) to regulate renal phosphate and vitamin D homeostasis. Soluble ...
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Article
Open AccessMyostatin regulates the production of fibroblast growth factor 23 (FGF23) in UMR106 osteoblast–like cells
Myostatin is a signaling molecule produced by skeletal muscle cells (myokine) that inhibits muscle hypertrophy and has further paracrine and endocrine effects in other organs including bone. Myostatin binds to...
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Article
Peroxisome proliferator–activated receptor α (PPARα)–dependent regulation of fibroblast growth factor 23 (FGF23)
Bone cells secrete fibroblast growth factor 23 (FGF23), a hormone that inhibits the synthesis of active vitamin D (1,25(OH)2D3) and induces phosphate excretion in the kidney. In addition, it exerts paracrine effe...