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  1. No Access

    Article

    Mitochondrial ATP generation is more proteome efficient than glycolysis

    Metabolic efficiency profoundly influences organismal fitness. Nonphotosynthetic organisms, from yeast to mammals, derive usable energy primarily through glycolysis and respiration. Although respiration is mor...

    Yihui Shen, Hoang V. Dinh, Edward R. Cruz, Zihong Chen… in Nature Chemical Biology (2024)

  2. No Access

    Article

    Activity-based RNA-modifying enzyme probing reveals DUS3L-mediated dihydrouridylation

    Epitranscriptomic RNA modifications can regulate RNA activity; however, there remains a major gap in our understanding of the RNA chemistry present in biological systems. Here we develop RNA-mediated activity-...

    Wei Dai, Ang Li, Nathan J. Yu, Thao Nguyen, Robert W. Leach… in Nature Chemical Biology (2021)