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within Martin Ingelsson Remove this filter Biomedicine Remove this filter Behavioral Sciences Remove this filter Neurosciences Remove this filter

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  1. Article

    Open Access

    Cryo-EM of Aβ fibrils from mouse models find tg-APPArcSwe fibrils resemble those found in patients with sporadic Alzheimer’s disease

    The use of transgenic mice displaying amyloid-β (Aβ) brain pathology has been essential for the preclinical assessment of new treatment strategies for Alzheimer’s disease. However, the properties of Aβ in such...

    Mara Zielinski, Fernanda S. Peralta Reyes, Lothar Gremer… in Nature Neuroscience (2023)

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    Article

    α-Synuclein strains target distinct brain regions and cell types

    The clinical and pathological differences between synucleinopathies such as Parkinson’s disease and multiple system atrophy have been postulated to stem from unique strains of α-synuclein aggregates, akin to w...

    Angus Lau, Raphaella W. L. So, Heather H. C. Lau, Jason C. Sang… in Nature Neuroscience (2020)