Page
%P
-
Article
MicroRNA regulation by RNA-binding proteins and its implications for cancer
Global downregulation of microRNA (miRNA) expression is an apparent feature of many tumours. Oncogenic or tumour-suppressive functions have been assigned to nu...
-
Article
A Pumilio-induced RNA structure switch in p27-3′ UTR controls miR-221 and miR-222 accessibility
Quiescent cells contain high levels of both the cell cycle inhibitor p27, and the miRNAs that should negatively regulate it. In response to growth factor, the RNA-binding protein PUM1 interacts with the 3′UTR ...