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    Monitoring Autophagy in Muscle Stem Cells

    Autophagy is critical not only for the cell’s adaptive response to starvation but also for cellular homeostasis, by acting as quality-control machinery for cytoplasmic components. This basal autophagic activit...

    Laura García-Prat, Pura Muñoz-Cánoves, Marta Martínez-Vicente in Muscle Stem Cells (2017)

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    Article

    Autophagy maintains stemness by preventing senescence

    During ageing, muscle stem-cell regenerative function declines. At advanced geriatric age, this decline is maximal owing to transition from a normal quiescence into an irreversible senescence state. How satell...

    Laura García-Prat, Marta Martínez-Vicente, Eusebio Perdiguero, Laura Ortet… in Nature (2016)

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    Protocol

    Methods for Mitochondria and Mitophagy Flux Analyses in Stem Cells of Resting and Regenerating Skeletal Muscle

    Mitochondria generate most of the cell’s supply of ATP as a source of energy. They are also implicated in the control of cell’s growth and death. Because of these critical functions, mitochondrial fitness is k...

    Laura García-Prat, Marta Martínez-Vicente… in Skeletal Muscle Regeneration in the Mouse (2016)

  4. No Access

    Article

    Autophagy maintains stemness by preventing senescence

    The regenerative properties of muscle stem cells decline with age as the stem cells enter an irreversible state of senescence; a study of mouse muscle stem cells reveals that entry into senescence is an autoph...

    Laura García-Prat, Marta Martínez-Vicente, Eusebio Perdiguero, Laura Ortet… in Nature (2016)

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    Reference Work Entry In depth

    Autophagic Pathways and Parkinson Disease

    Autophagy is responsible for the degradation and recycling of intracellular material including organelles, cytosolic proteins, and accumulated misfolded proteins. Increasing evidence implicates autophagy dysfu...

    Miquel Vila, Marta Martínez-Vicente in Handbook of Neurotoxicity (2014)

  6. No Access

    Article

    Fighting neurodegeneration with rapamycin: mechanistic insights

  7. Multiple independent studies have recently shown that rapamycin, a US Food and Drug Administration (FDA)-approved antibiotic and immunosuppressant currently us...

    8. Jordi Bové, Marta Martínez-Vicente, Miquel Vila in Nature Reviews Neuroscience (2011)

  8. No Access

    Article

    Letter to the Editor: Backbone 1H, 13C and 15N Resonance Assignments for the 18.7 kDa GTPase Domain of Escherichia Coli MnmE Protein

    Daniel Monleón, Lucía Yim, Marta Martínez-Vicente… in Journal of Biomolecular NMR (2004)