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within Mark W Pellegrino Remove this filter Science, Humanities and Social Sciences, multidisciplinary Remove this filter

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  1. No Access

    Article

    Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection

    A link between an intracellular stress response, bacterial infection and triggering of the innate immune response is shown in Caenorhabditis elegans; exposure to the pathogen Pseudomonas aeruginosa caused activat...

    Mark W. Pellegrino, Amrita M. Nargund, Natalia V. Kirienko, Reba Gillis… in Nature (2014)

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    Article

    Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response

    In the context of mitochondrial genome heteroplasmy that causes defective oxidative phosphorylation in C. elegans, the ATFS-1-mediated mitochondrial unfolded protein response maintains the deleterious mitochondri...

    Yi-Fan Lin, Anna M. Schulz, Mark W. Pellegrino, Yun Lu, Shai Shaham… in Nature (2016)