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  1. Article

    Development of a 950-gene DNA array for examining gene expression patterns in mouse testis

    Over the past five years, interest in and use of DNA array technology has increased dramatically, and there has been a surge in demand for different types of arrays. Although manufacturers offer a number of pr...

    John C Rockett, J Christopher Luft, J Brian Garges, Stephen A Krawetz… in Genome Biology (2001)

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    Article

    Terminal restriction fragment length polymorphism monitoring of genes amplified directly from bacterial communities in soils and sediments

    Terminal Restriction Fragment Length Polymorphism (T-RFLP) or Fluorescent Polymerase Chain Reaction/Restriction Fragment Length Polymorphism (FluRFLP) have made a significant impact on the way in which PCR pro...

    Kenneth D. Bruce, Mark R. Hughes in Molecular Biotechnology (2000)

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    Fluorescent Polymerase Chain Reaction/Restriction Fragment Length Polymorphism Monitoring of Genes Amplified Directly from Bacterial Communities in Soils and Sediments

    There has been a growing acknowledgment of both the ecological and biotechnological importance of microbes in natural environments. Concerns about the nonrepresentative nature of traditional analytical methods...

    Kenneth D. Bruce, Mark R. Hughes in Environmental Monitoring of Bacteria (1999)

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    Article

    Gametic and somatic tissue–specific heterogeneity of the expanded SCA1 CAG repeat in spinocerebellar ataxia type 1

    Spinocerebellar ataxia type 1 is associated with expansion of an unstable CAG repeat within the SCA1 gene. Male gametic heterogeneity of the expanded repeat is demonstrated using single sperm and low–copy genome ...

    Samuel S. Chong, Alanna E. McCall, Juan Cota, S.H. Subramony… in Nature Genetics (1995)

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    Article

    Preimplantation single cell analyses of dystrophin gene deletions using whole genome amplification

    Primer extension preamplification (PEP) increases the scope and capacity of single cell genetic diagnosis by generating sufficient template to perform multiple subsequent DNA analyses using the polymerase chai...

    Kristleifur Kristjansson, Samuel S. Chong, Ignatia B. Van den Veyver… in Nature Genetics (1994)

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    Article

    Cryopreserved mouse embryos can successfully survive biopsy and refreezing

    We examined whether cryopreserved mouse eight-cell embryos could be thawed, biopsied, refrozen, thawed, and grown in vitro and in vivo in two sets of experiments.

    Michael C. Snabes, Juan Cota, Mark R. Hughes in Journal of Assisted Reproduction and Genet… (1993)

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    Chapter

    Hypocalcemia and Hypercalcemia

    Calcium is the fifth most abundant inorganic element of the body, the principal component of the human skeleton, and a vital participant in normal neuromuscular function, blood coagulation, membrane function, ...

    Mark R. Hughes, Wadi N. Suki in Therapy of Renal Diseases and Related Disorders (1984)

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    Article

    Presence of 1,25-dihydroxyvitamin D3-glycoside in the calcinogenic plant Cestrum diurnum

    A DISEASE clinically and morphologically similar to vitamin D-intoxication, characterised by hypercalcaemia and extensive soft tissue calcification, has been described in grazing animals and linked to the inge...

    MARK R. HUGHES, TONI A. MCCAIN, SAI Y. CHANG, MARK R. HAUSSLER… in Nature (1977)