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Article
An Opportunity for Constructing the Future of Data Sharing in Otolaryngology
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Chapter and Conference Paper
Dyslexia Data Consortium Repository: A Data Sharing and Delivery Platform for Research
Specific learning disability of reading, or dyslexia, affects 5–17% of the population in the United States. Research on the neurobiology of dyslexia has included studies with relatively small sample sizes acro...
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Article
Metabolic and Sensory Components of Age-Related Hearing Loss
Age-related hearing loss is a multifactorial condition with effects of aging and environmental exposures that contribute to cochlear pathologies. Metabolic hearing loss involves declines in the endocochlear po...
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Protocol
Isolation of Normal and Cancer-Associated Fibroblasts
Cancer-associated fibroblasts (CAFs) play important roles in regulating tumor progression, metastasis, and response to therapies. Accurately modeling the interplay between cancer cells and the tumor microenvir...
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Article
Unique patterns of hearing loss and cognition in older adults’ neural responses to cues for speech recognition difficulty
Older adults with hearing loss experience significant difficulties understanding speech in noise, perhaps due in part to limited benefit from supporting executive functions that enable the use of environmental...
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Article
Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts
High-grade serous carcinoma has a poor prognosis, owing primarily to its early dissemination throughout the abdominal cavity. Genomic and proteomic approaches have provided snapshots of the proteogenomics of o...
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Article
Open AccessMutant p53 regulates LPA signaling through lysophosphatidic acid phosphatase type 6
Emerging evidence has indicated that high-grade serous ovarian cancer (HGSOC) originates in the fallopian tube, where the earliest known genetic lesion is the mutation of TP53. In addition to such genetic changes...
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Article
m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer
N6-methyladenosine (m6A) messenger RNA methylation is a gene regulatory mechanism affecting cell differentiation and proliferation in development and cancer. To study the roles of m6A mRNA methylation in cell pro...
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Article
Open AccessA Novel Communication Value Task Demonstrates Evidence of Response Bias in Cases with Presbyacusis
Decision-making about the expected value of an experience or behavior can explain hearing health behaviors in older adults with hearing loss. Forty-four middle-aged to older adults (68.45 ± 7.73 years) perform...
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Article
Open AccessAn activity-dependent proximity ligation platform for spatially resolved quantification of active enzymes in single cells
Integration of chemical probes into proteomic workflows enables the interrogation of protein activity, rather than abundance. Current methods limit the biological contexts that can be addressed due to sample h...
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Article
Open AccessCommon Brain Structure Findings Across Children with Varied Reading Disability Profiles
Dyslexia is a developmental disorder in reading that exhibits varied patterns of expression across children. Here we examined the degree to which different kinds of reading disabilities (defined as profiles or...
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Article
Longitudinal Changes in Audiometric Phenotypes of Age-Related Hearing Loss
Presbyacusis, or age-related hearing loss, can be characterized in humans as metabolic and sensory phenotypes, based on patterns of audiometric thresholds that were established in animal models. The metabolic ...
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Article
Classifying Human Audiometric Phenotypes of Age-Related Hearing Loss from Animal Models
Age-related hearing loss (presbyacusis) has a complex etiology. Results from animal models detailing the effects of specific cochlear injuries on audiometric profiles may be used to understand the mechanisms u...
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Article
White Matter Hyperintensities Predict Low Frequency Hearing in Older Adults
Vascular disease has been proposed as a contributing factor for presbyacusis (age-related hearing loss). While this hypothesis is supported by pathological evidence of vascular decline in post-mortem human and...
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Article
Auditory Cortex Signs of Age-Related Hearing Loss
Age-related hearing loss, or presbyacusis, is a major public health problem that causes communication difficulties and is associated with diminished quality of life. Limited satisfaction with hearing aids, par...
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Article
Age-related Effects on Word Recognition: Reliance on Cognitive Control Systems with Structural Declines in Speech-responsive Cortex
Speech recognition can be difficult and effortful for older adults, even for those with normal hearing. Declining frontal lobe cognitive control has been hypothesized to cause age-related speech recognition pr...
