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Article
Personal exposure to PM2.5 oxidative potential and its association to birth outcomes
Prenatal exposure to fine particulate matter (PM2.5) assessed through its mass concentration has been associated with foetal growth restriction in studies based on outdoor levels. Oxidative potential of PM2.5 (OP...
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Article
Open AccessPlacental multi-omics integration identifies candidate functional genes for birthweight
Abnormal birthweight is associated with increased risk for cardiometabolic diseases in later life. Although the placenta is critical to fetal development and later life health, it has not been integrated into ...
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Article
Associations of maternal blood pressure-raising polygenic risk scores with fetal weight
Maternal blood pressure (BP) is associated with variations in fetal weight, an important determinant of neonatal and adult health. However, the association of BP-raising genetic risk with fetal weight is unkno...
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Article
Admixture map** identifies African and Amerindigenous local ancestry loci associated with fetal growth
Fetal growth is an important determinant of cardiometabolic disease risk during childhood and adulthood. The genetic architecture of fetal growth remains largely understudied in ancestrally diverse populations...
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Article
Open AccessPleiotropic genetic influence on birth weight and childhood obesity
Childhood obesity is a global public health problem. Understanding the molecular mechanisms that underlie early origins of childhood obesity can facilitate interventions. Consistent phenotypic and genetic corr...
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Article
Open AccessConcentrations of persistent organic pollutants in maternal plasma and epigenome-wide placental DNA methylation
Prenatal maternal plasma persistent organic pollutant (POP) concentrations have been associated with neonatal outcomes. However, the underlying mechanisms remain unknown. Placental epigenetic mechanisms may be...
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Article
Open AccessDNA methylation loci in placenta associated with birthweight and expression of genes relevant for early development and adult diseases
Birthweight marks an important milestone of health across the lifespan, including cardiometabolic disease risk in later life. The placenta, a transient organ at the maternal-fetal interface, regulates fetal gr...
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Article
Placental DNA methylation changes associated with maternal prepregnancy BMI and gestational weight gain
Maternal obesity prior to or during pregnancy influences fetal growth, predisposing the offspring to increased risk for obesity across the life course. Placental epigenetic mechanisms may underlie these associ...
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Article
Open AccessGenetic overlap between birthweight and adult cardiometabolic diseases has implications for genomic medicine
Before implementing therapeutic genomic interventions for optimizing health in early life, comprehensive understanding of their effect on several traits across the life course is warranted. Abnorml birthweigh...
