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  1. No Access

    Chapter

    Adoptive T-Cell Therapy: Optimizing Chemokine Receptor-Mediated Homing of T-Cells in Cancer Immunotherapy

    Immunotherapy based on adoptive T-cell transfer provides a promising form of cancer therapy, but often fails to induce long-lasting responses in the great majority of patients. During the past few decades, sev...

    Imran Siddiqui, Debora Vignali, Marinos Kallikourdis… in Cancer Immunology (2021)

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    Chapter

    The WHIM Syndrome

    The WHIM syndrome is a rare immunodeficiency characterized by Warts, Hypogammaglobulinemia, recurrent respiratory bacterial Infections, and Myelokathexis. Early studies identified that neutrophils in WHIM pati...

    Giuliana Roselli, Marinos Kallikourdis… in Humoral Primary Immunodeficiencies (2019)

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    Article

    T cell responses to tumor: how dominant assumptions on immune activity led to a neglect of pathological functions, and how evolutionary considerations can help identify testable hypotheses for improving immunotherapy

    Cancer immunotherapy is based on the premise that activated, pro-inflammatory T cell responses to tumor will mostly combat tumor growth. Nowadays accepted as largely valid, this hypothesis has been formed as a...

    Marinos Kallikourdis in Cancer Immunology, Immunotherapy (2018)