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  1. No Access

    Chapter

    Adoptive T-Cell Therapy: Optimizing Chemokine Receptor-Mediated Homing of T-Cells in Cancer Immunotherapy

    Immunotherapy based on adoptive T-cell transfer provides a promising form of cancer therapy, but often fails to induce long-lasting responses in the great majority of patients. During the past few decades, sev...

    Imran Siddiqui, Debora Vignali, Marinos Kallikourdis… in Cancer Immunology (2021)

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    Chapter

    The WHIM Syndrome

    The WHIM syndrome is a rare immunodeficiency characterized by Warts, Hypogammaglobulinemia, recurrent respiratory bacterial Infections, and Myelokathexis. Early studies identified that neutrophils in WHIM pati...

    Giuliana Roselli, Marinos Kallikourdis… in Humoral Primary Immunodeficiencies (2019)

  3. No Access

    Article

    T cell responses to tumor: how dominant assumptions on immune activity led to a neglect of pathological functions, and how evolutionary considerations can help identify testable hypotheses for improving immunotherapy

    Cancer immunotherapy is based on the premise that activated, pro-inflammatory T cell responses to tumor will mostly combat tumor growth. Nowadays accepted as largely valid, this hypothesis has been formed as a...

    Marinos Kallikourdis in Cancer Immunology, Immunotherapy (2018)

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    Chapter

    Chemokines and T Cell Trafficking into Tumors: Strategies to Enhance Recruitment of T Cells into Tumors

    Chemokines are small proteins used by the cells of the immune system in order to orchestrate their movement in the body during physiological and pathological conditions. Yet they are also expressed in tumors a...

    Stefano Garetto, Claudia Sardi, Diego Morone… in Defects in T Cell Trafficking and Resistan… (2016)

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    Article

    Regulatory T cells mediate maternal tolerance to the fetus

    Pregnancy constitutes a major challenge to the maternal immune system, as it has to tolerate the persistence of paternal alloantigen. Although localized mechanisms contribute to fetal evasion from immune attac...

    Varuna R Aluvihare, Marinos Kallikourdis, Alexander G Betz in Nature Immunology (2004)

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    Article

    B cells and professional APCs recruit regulatory T cells via CCL4

    Using gene expression profiling, we show here that activation of B cells and professional antigen-presenting cells (APCs) induces the expression of common chemokines. Among these, CCL4 was the most potent chem...

    Richard S. Bystry, Varuna Aluvihare, Katie A. Welch… in Nature Immunology (2001)