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Chapter and Conference Paper
DNA Barcoding of Waldsteinia Willd. (Rosaceae) Species Based on ITS and trnH-psbA Nucleotide Sequences
The methods of biological species identification using nucleotide sequences of short genome regions (DNA markers) are actively developed. This principle formed the basis of the genetic database purposed the id...
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Article
An inhibitor of oxidative phosphorylation exploits cancer vulnerability
Metabolic reprograming is an emerging hallmark of tumor biology and an actively pursued opportunity in discovery of oncology drugs. Extensive efforts have focused on therapeutic targeting of glycolysis, wherea...
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Article
Can acclimation of amphipods change their antioxidative response?
The aim of this study was to evaluate whether experimental conditions, particularly duration of acclimation in the laboratory with artificial water and diet prior to the actual experiment, can affect the antio...
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Article
Small molecule RITA binds to p53, blocks p53–HDM-2 interaction and activates p53 function in tumors
In tumors that retain wild-type p53, its tumor-suppressor function is often impaired as a result of the deregulation of HDM-2, which binds to p53 and targets it for proteasomal degradation. We have screened a ...
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Article
Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway
Recent evidence identified a genetic and functional link between Chk2 kinase and p53 as a candidate genome integrity checkpoint and a tumour suppressor pathway. Here we report that in human cells, Chk2 and p53...
