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Article
Open AccessComparison of mixed model based approaches for correcting for population substructure with application to extreme phenotype sampling
Mixed models are used to correct for confounding due to population stratification and hidden relatedness in genome-wide association studies. This class of models includes linear mixed models and generalized li...
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Article
Open AccessApplication of the regression of offspring on mid-parent method to detect associations between single-nucleotide polymorphisms and the beta 2 electroencephalogram phenotype in the COGA data
The beta 2 electroencephalogram (EEG) phenotype is used as a quantitative measure related to alcoholism, and evidence of linkage and association has previously been reported in the Collaborative Study on the G...
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Article
Open AccessComparison of year-of-exam- and age-matched estimates of heritability in the Framingham Heart Study data
Several different approaches can be used to examine generational and temporal trends in family studies. The measurement of offspring and parents can be made over a short period of time with parents and offspri...