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    Article

    Mechanism of high-mannose N-glycan breakdown and metabolism by Bifidobacterium longum

    Bifidobacteria are early colonizers of the human gut and play central roles in human health and metabolism. To thrive in this competitive niche, these bacteria evolved the capacity to use complex carbohydrates...

    Rosa L. Cordeiro, Camila R. Santos, Mariane N. Domingues in Nature Chemical Biology (2023)

  2. Article

    Open Access

    Gut microbiome of the largest living rodent harbors unprecedented enzymatic systems to degrade plant polysaccharides

    The largest living rodent, capybara, can efficiently depolymerize and utilize lignocellulosic biomass through microbial symbiotic mechanisms yet elusive. Herein, we elucidate the microbial community compositio...

    Lucelia Cabral, Gabriela F. Persinoti, Douglas A. A. Paixão in Nature Communications (2022)

  3. Article

    Open Access

    Two distinct catalytic pathways for GH43 xylanolytic enzymes unveiled by X-ray and QM/MM simulations

    Xylanolytic enzymes from glycoside hydrolase family 43 (GH43) are involved in the breakdown of hemicellulose, the second most abundant carbohydrate in plants. Here, we kinetically and mechanistically describe ...

    Mariana A. B. Morais, Joan Coines, Mariane N. Domingues in Nature Communications (2021)

  4. Article

    Publisher Correction: Structural insights into β-1,3-glucan cleavage by a glycoside hydrolase family

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    Camila R. Santos, Pedro A. C. R. Costa, Plínio S. Vieira in Nature Chemical Biology (2020)

  5. No Access

    Article

    Structural insights into β-1,3-glucan cleavage by a glycoside hydrolase family

    The fundamental and assorted roles of β-1,3-glucans in nature are underpinned on diverse chemistry and molecular structures, demanding sophisticated and intricate enzymatic systems for their processing. In thi...

    Camila R. Santos, Pedro A. C. R. Costa, Plínio S. Vieira in Nature Chemical Biology (2020)

  6. Article

    Open Access

    Identification of putative TAL effector targets of the citrus canker pathogens shows functional convergence underlying disease development and defense response

    Transcriptional activator-like (TAL) effectors, formerly known as the AvrBs3/PthA protein family, are DNA-binding effectors broadly found in Xanthomonas spp. that transactivate host genes upon injection via the b...

    Andre LA Pereira, Marcelo F Carazzolle, Valeria Y Abe, Maria LP de Oliveira in BMC Genomics (2014)