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  1. No Access

    Article

    Multilayered VBC score predicts sgRNAs that efficiently generate loss-of-function alleles

    CRISPR–Cas9 screens have emerged as a transformative approach to systematically probe gene functions. The quality and success of these screens depends on the frequencies of loss-of-function alleles, particular...

    Georg Michlits, Julian Jude, Matthias Hinterndorfer, Melanie de Almeida… in Nature Methods (2020)

  2. No Access

    Article

    CRISPR-UMI: single-cell lineage tracing of pooled CRISPR–Cas9 screens

    Combining each sgRNA with a unique molecular identifier in a genome-wide screen increases sensitivity and robustness in both positive and negative selection.

    Georg Michlits, Maria Hubmann, Szu-Hsien Wu, Gintautas Vainorius… in Nature Methods (2017)