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  1. No Access

    Article

    Inactivation of MAPK in epididymal fat and amelioration of triglyceride secretion by injection of GRK2 siRNA in ob/ob mice

    Abnormal G protein-coupled receptor kinase 2 (GRK2) accumulation has a crucial role in the development of insulin resistance and diabetes. Although GRK2 siRNA transfection in the liver improves insulin resista...

    Kumiko Taguchi, Nanami Bessho, Mari Hida… in Naunyn-Schmiedeberg's Archives of Pharmaco… (2018)

  2. Article

    Open Access

    Suppression of GRK2 expression reduces endothelial dysfunction by restoring glucose homeostasis

    Despite the associations between diabetic complications and vascular endothelial dysfunction, a direct therapeutic method targeting endothelial dysfunction remains poorly characterized. We have previously show...

    Kumiko Taguchi, Mari Hida, Mami Hasegawa, Haruka Narimatsu… in Scientific Reports (2017)

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  3. No Access

    Article

    Glucose and angiotensin II-derived endothelial extracellular vesicles regulate endothelial dysfunction via ERK1/2 activation

    In various diseases, including diabetes, extracellular vesicles (EVs) have been detected in circulation and tissues. EVs are small membrane vesicles released from various cell types under varying conditions. R...

    Kumiko Taguchi, Mari Hida, Haruka Narimatsu… in Pflügers Archiv - European Journal of Phys… (2017)