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  1. Article

    Author Correction: Small-molecule-mediated control of the anti-tumour activity and off-tumour toxicity of a supramolecular bispecific T cell engager

    Ningqiang Gong, Xuexiang Han, Lulu Xue… in Nature Biomedical Engineering (2024)

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    Article

    Small-molecule-mediated control of the anti-tumour activity and off-tumour toxicity of a supramolecular bispecific T cell engager

    The broader clinical use of bispecific T cell engagers for inducing anti-tumour toxicity is hindered by their on-target off-tumour toxicity and the associated neurotoxicity and cytokine-release syndrome. Here ...

    Ningqiang Gong, Xuexiang Han, Lulu Xue… in Nature Biomedical Engineering (2024)

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    Article

    In situ PEGylation of CAR T cells alleviates cytokine release syndrome and neurotoxicity

    Chimeric antigen receptor T (CAR T) cell immunotherapy is successful at treating many cancers. However, it often induces life-threatening cytokine release syndrome (CRS) and neurotoxicity. Here, we show that i...

    Ningqiang Gong, Xuexiang Han, Lulu Xue, Rakan El-Mayta, Ann E. Metzloff… in Nature Materials (2023)

  4. Article

    Open Access

    Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis

    Lipid nanoparticle-mediated RNA delivery holds great potential to treat various liver diseases. However, targeted delivery of RNA therapeutics to activated liver-resident fibroblasts for liver fibrosis treatme...

    Xuexiang Han, Ningqiang Gong, Lulu Xue, Margaret M. Billingsley… in Nature Communications (2023)

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  5. Article

    Engineering precision nanoparticles for drug delivery

    In recent years, the development of nanoparticles has expanded into a broad range of clinical applications. Nanoparticles have been developed to overcome the limitations of free therapeutics and navigate biolo...

    Michael J. Mitchell, Margaret M. Billingsley… in Nature Reviews Drug Discovery (2021)

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    Article

    Nanomaterials for T-cell cancer immunotherapy

    T-cell-based immunotherapies hold promise for the treatment of many types of cancer, with three approved products for B-cell malignancies and a large pipeline of treatments in clinical trials. However, there a...

    Ningqiang Gong, Neil C. Sheppard, Margaret M. Billingsley… in Nature Nanotechnology (2021)

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    Protocol

    Quantification of siRNA Duplexes Bound to Gold Nanoparticle Surfaces

    RNA interference (RNAi)-based gene regulation has recently emerged as a promising strategy to silence genes that drive disease progression. RNAi is typically mediated by small interfering ribonucleic acids (si...

    Jilian R. Melamed, Rachel S. Riley, Danielle M. Valcourt… in Biomedical Nanotechnology (2017)