11 Result(s)
within
Marco Erreni
English
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Protocol
Assessing the Nanoscale Organization of Excitatory and Inhibitory Synapses Using Recombinant Probes to Visualize Endogenous Synaptic Proteins
Synapses are highly dynamic and complex structures responsible for neuronal communication. The recent progresses in super-resolution imaging technologies unraveled an inherently complex nanorganization of syna...
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Article
Heme catabolism by tumor-associated macrophages controls metastasis formation
Although the pathological significance of tumor-associated macrophage (TAM) heterogeneity is still poorly understood, TAM reprogramming is viewed as a promising anticancer therapy. Here we show that a distinct...
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Protocol
Method for Acute Intravital Imaging of the Large Intestine in Live Mice
Intravital microscopy is an imaging technique aimed at the visualization of the dynamics of biological processes in live animals. In the last decade, the development of nonlinear optical microscopy has enormou...
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Article
Open AccessAuthor Correction: Evaluation of cell metabolic adaptation in wound and tumour by Fluorescence Lifetime Imaging Microscopy
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessEvaluation of cell metabolic adaptation in wound and tumour by Fluorescence Lifetime Imaging Microscopy
Acidic pH occurs in acute wounds progressing to healing as consequence of a cell metabolic adaptation in response to injury-induced tissue hypoperfusion. In tumours, high metabolic rate leads to acidosis affec...
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Article
Open AccessPSMA expression level predicts differentiated thyroid cancer aggressiveness and patient outcome
Prostate-specific membrane antigen (PSMA) is overexpressed on the endothelial cells of tumor neo-vessels of several solid malignancies, including differentiated thyroid cancer (DTC). We aimed to test the poten...
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Article
Open AccessSenescent thyrocytes and thyroid tumor cells induce M2-like macrophage polarization of human monocytes via a PGE2-dependent mechanism
Thyroid carcinoma includes several variants characterized by different biological and clinical features: from indolent microcarcinoma to undifferentiated and aggressive anaplastic carcinoma. Inflammation plays...
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Article
Open AccessEnhanced recruitment of genetically modified CX3CR1-positive human T cells into Fractalkine/CX3CL1 expressing tumors: importance of the chemokine gradient
Adoptive T-cell based immunotherapies constitute a promising approach to treat cancer, however, a major problem is to obtain effective and long-lasting anti-tumor responses. Lack of response may be due to insu...
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Article
Macrophage polarization in pathology
Macrophages are cells of the innate immunity constituting the mononuclear phagocyte system and endowed with remarkable different roles essential for defense mechanisms, development of tissues, and homeostasis....
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Article
Tumor-associated Macrophages (TAM) and Inflammation in Colorectal Cancer
Experimental and epidemiological studies indicate a strong link between chronic inflammation and tumor progression. Human colorectal cancer (CRC), a major cause of cancer-related death in Western countries, re...
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Article
RAI(ShcC/N-Shc)-dependent recruitment of GAB1 to RET oncoproteins potentiates PI3-K signalling in thyroid tumors
RAI, also named ShcC/N-Shc, one of the members of the Shc proteins family, is a substrate of the RET receptor tyrosine kinase. Here, we show that RAI forms a protein complex with both RET/MEN2A and RET/PTC onc...
