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  1. Article

    Open Access

    WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage

    Perturbation in the replication-stress response (RSR) and DNA-damage response (DDR) causes genomic instability. Genomic instability occurs in Wiskott-Aldrich syndrome (WAS), a primary immunodeficiency disorder...

    Seong-Su Han, Kuo-Kuang Wen, María L. García-Rubio, Marc S. Wold… in Nature Communications (2022)

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  2. No Access

    Article

    A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo

    In many repeat diseases, such as Huntington’s disease (HD), ongoing repeat expansions in affected tissues contribute to disease onset, progression and severity. Inducing contractions of expanded repeats by exo...

    Masayuki Nakamori, Gagan B. Panigrahi, Stella Lanni, Terence Gall-Duncan… in Nature Genetics (2020)

  3. No Access

    Article

    Dynamics and selective remodeling of the DNA-binding domains of RPA

    Replication protein A (RPA) coordinates important DNA metabolic events by stabilizing single-stranded DNA (ssDNA) intermediates, activating the DNA-damage response and handing off ssDNA to the appropriate down...

    Nilisha Pokhrel, Colleen C. Caldwell… in Nature Structural & Molecular Biology (2019)

  4. No Access

    Protocol

    Detection of Posttranslational Modifications of Replication Protein A

    Replication Protein A (RPA) is a single-strand DNA-binding protein that is found in all eukaryotes. RPA is subjected to multiple posttranslational modifications including serine- and threonine-phosphorylation,...

    Cathy S. Hass, Ran Chen, Marc S. Wold in Single-Stranded DNA Binding Proteins (2012)

  5. No Access

    Article

    A common means to an end

    Analyses of telomere-binding proteins show structural and functional conservation with subunits of replication protein A, the canonical single-stranded DNA–binding protein. These studies raise intriguing quest...

    Stuart J Haring, Marc S Wold in Nature Structural & Molecular Biology (2007)

  6. No Access

    Article

    Specific down-regulation of annexin II expression in human cells interferes with cell proliferation

    The protein-tyrosine kinase substrate annexin II is a growth regulated gene whose expression is increased in several human cancers. While the precise function of this protein is not understood, annexin II is p...

    Yang** Chiang, Angie Rizzino, Zita A. Sibenaller… in Molecular and Cellular Biochemistry (1999)

  7. No Access

    Article

    Human replication protein A: Global fold of the N-terminal RPA-70 domain reveals a basic cleft and flexible C-terminal linker†

    Human Replication Protein A (hsRPA) is required for multiple cellular processes in DNA metabolism including DNA repair, replication and recombination. It binds single-stranded DNA with high affinity and intera...

    Doris M. Jacobs, Andrew S. Lipton, Nancy G. Isern… in Journal of Biomolecular NMR (1999)

  8. No Access

    Article

    RPA involvement in the damage-recognition and incision steps of nucleotide excision repair

    HUMAN replication protein (RPA) functions in DNA replication1-4, homologous recombination5 and nucleotide excision repair6. This multisubunit single-stranded DNA-binding protein1,2 may be required to make unique ...

    Zhigang He, Leigh A. Henricksen, Marc S. Wold, C. James Ingles in Nature (1995)

  9. No Access

    Chapter and Conference Paper

    SV40 DNA Replication with Purified Proteins: Functional Interactions Among the Initiation Proteins

    Simian virus 40 (SV40), has proved to be a useful model system for the study of mammalian DNA replication (Challberg and Kelly 1989; Hurwitz et al. 1990; Kelly 1988; Stillman 1989). The SV40 genome is replicated ...

    Kathleen L. Collins, Lome F. Erdile… in DNA Replication: The Regulatory Mechanisms (1992)