-
Article
Open AccessCorrection to: Anatomic survey of seeding in Alzheimer’s disease brains reveals unexpected patterns
-
Article
Open AccessFTD-tau S320F mutation stabilizes local structure and allosterically promotes amyloid motif-dependent aggregation
Amyloid deposition of the microtubule-associated protein tau is associated with neurodegenerative diseases. In frontotemporal dementia with abnormal tau (FTD-tau), missense mutations in tau enhance its aggrega...
-
Article
Open AccessNetwork of hotspot interactions cluster tau amyloid folds
Cryogenic electron microscopy has revealed unprecedented molecular insight into the conformations of β-sheet-rich protein amyloids linked to neurodegenerative diseases. It remains unknown how a protein can ado...
-
Article
Open AccessThe AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system
Amyloid-like aggregates of the microtubule-associated protein Tau are associated with several neurodegenerative disorders including Alzheimer’s disease. The existence of cellular machinery for the removal of s...
-
Article
Open AccessTau seeding in cases of multiple sclerosis
Relapsing remitting multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system that in many cases leads to progressive MS, a neurodegenerative disease. Progressive MS is un...
-
Article
Open AccessVCP suppresses proteopathic seeding in neurons
Neuronal uptake and subsequent spread of proteopathic seeds, such as αS (alpha-synuclein), Tau, and TDP-43, contribute to neurodegeneration. The cellular machinery participating in this process is poorly under...
-
Article
Tau seeding in chronic traumatic encephalopathy parallels disease severity
Chronic traumatic encephalopathy (CTE), a neurodegenerative tauopathy, is associated with behavioral, mood and cognitive impairment, including dementia. Tauopathies are neurodegenerative diseases whose neuropa...
-
Article
Open AccessDeep learning reveals disease-specific signatures of white matter pathology in tauopathies
Although pathology of tauopathies is characterized by abnormal tau protein aggregation in both gray and white matter regions of the brain, neuropathological investigations have generally focused on abnormaliti...
-
Article
Open AccessAnatomic survey of seeding in Alzheimer’s disease brains reveals unexpected patterns
Tauopathies are heterogeneous neurodegenerative diseases defined by progressive brain accumulation of tau aggregates. The most common tauopathy, sporadic Alzheimer’s disease (AD), involves progressive tau depo...
-
Article
Open AccessTau strains shape disease
Tauopathies consist of over 25 different neurodegenerative diseases that include argyrophilic grain disease (AGD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and Pick’s disease (PiD...
-
Article
Open AccessUltrasensitive tau biosensor cells detect no seeding in Alzheimer’s disease CSF
Tau protein forms self-replicating assemblies (seeds) that may underlie progression of pathology in Alzheimer’s disease (AD) and related tauopathies. Seeding in recombinant protein preparations and brain homog...
-
Article
Open AccessTau local structure shields an amyloid-forming motif and controls aggregation propensity
Tauopathies are neurodegenerative diseases characterized by intracellular amyloid deposits of tau protein. Missense mutations in the tau gene (MAPT) correlate with aggregation propensity and cause dominantly inhe...
-
Article
Rebuttal to Drs. Grinberg and Heinsen
-
Article
Open AccessTau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer’s disease and PART
Alzheimer’s disease (AD) is characterized by accumulation of tau neurofibrillary tangles (NFTs) and, according to the prion model, transcellular propagation of pathological “seeds” may underlie its progression...
-
Article
Open AccessThe CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition
MAPT mutations cause neurodegenerative diseases such as frontotemporal dementia but, strikingly, patients with the same mutation may have different clinical phenotypes.
-
Article
Open AccessCharacterization of tau prion seeding activity and strains from formaldehyde-fixed tissue
Tauopathies such as Alzheimer’s disease (AD) feature progressive intraneuronal deposition of aggregated tau protein. The cause is unknown, but in experimental systems trans-cellular propagation of tau patholog...
-
Article
Ultrasensitive and selective detection of 3-repeat tau seeding activity in Pick disease brain and cerebrospinal fluid
The diagnosis and treatment of diseases involving tau-based pathology such as Alzheimer disease and certain frontotemporal dementias is hampered by the inability to detect pathological forms of tau with suffic...
-
Protocol
FRET and Flow Cytometry Assays to Measure Proteopathic Seeding Activity in Biological Samples
Transcellular propagation of protein aggregates—or seeds—is increasingly implicated as a mechanism for disease progression in many neurodegenerative disorders, including Alzheimer’s disease and the related tau...
-
Article
Widespread tau seeding activity at early Braak stages
Transcellular propagation of tau aggregates may underlie the progression of pathology in Alzheimer’s disease (AD) and other tauopathies. Braak staging (B1, B2, B3) is based on phospho-tau accumulation within c...
-
Article
Neuronal activity enhances tau propagation and tau pathology in vivo
The authors show that tau can be released by neurons and transferred to other neurons via the extracellular space. Moreover, they show that enhancing neuronal activity accelerates transneuronal tau propagation...
