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  1. No Access

    Article

    Expansion of KRAS hotspot mutations reactive T cells from human pancreatic tumors using autologous T cells as the antigen-presenting cells

    Adoptive cell therapy (ACT) with expanded tumor-infiltrating lymphocytes (TIL) or TCR gene-modified T cells (TCR-T) that recognize mutant KRAS neo-antigens can mediate tumor regression in patients with advance...

    Sizhen Wang, **aohui Zhang, Xuemei Zou, Maorong Wen… in Cancer Immunology, Immunotherapy (2023)

  2. Article

    Open Access

    PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain

    The cytoplasmic domain of PD-L1 (PD-L1-CD) regulates PD-L1 degradation and stability through various mechanism, making it an attractive target for blocking PD-L1-related cancer signaling. Here, by using NMR an...

    Maorong Wen, Yunlei Cao, Bin Wu, Taoran **ao, Ruiyu Cao, Qian Wang… in Nature Communications (2021)

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