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Article
Host–microbe metabolic dialogue
Metabolomics and feeding experiments demonstrate the host’s active role in sharing organic acids with a gut microbiota member, revealing host–microbe interactions that foster symbiosis.
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Article
Open AccessmicrobeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data
microbeMASST, a taxonomically informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging a curated database of >60,000 micro...
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Article
Open AccessDie chemische Sprache von Symbiosen sichtbar machen
Small molecules — metabolites — provide the basis for chemical interactions between hosts and microbes. Especially in animal-microbe symbioses, the close physical interactions require a spatial organization of...
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Article
Verrucomicrobia use hundreds of enzymes to digest the algal polysaccharide fucoidan
Brown algae are important players in the global carbon cycle by fixing carbon dioxide into 1 Gt of biomass annually, yet the fate of fucoidan—their major cell wall polysaccharide—remains poorly understood. Mic...
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Article
Spatial metabolomics of in situ host–microbe interactions at the micrometre scale
Spatial metabolomics describes the location and chemistry of small molecules involved in metabolic phenotypes, defence molecules and chemical interactions in natural communities. Most current techniques are un...
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Article
Open AccessTwo intracellular and cell type-specific bacterial symbionts in the placozoan Trichoplax H2
Placozoa is an enigmatic phylum of simple, microscopic, marine metazoans1,2. Although intracellular bacteria have been found in all members of this phylum, almost nothing is known about their identity, location a...
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Article
Open AccessRole of N-terminal protein formylation in central metabolic processes in Staphylococcus aureus
Bacterial protein biosynthesis usually depends on a formylated methionyl start tRNA but Staphylococcus aureus is viable in the absence of Fmt, the tRNAMet formyl transferase. fmt mutants exhibit reduced growth ra...