37 Result(s)
within
Manon J N L Benders
Pediatrics
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Article
Brain injury and long-term outcome after neonatal surgery for non-cardiac congenital anomalies
There is growing evidence that neonatal surgery for non-cardiac congenital anomalies (NCCAs) in the neonatal period adversely affects long-term neurodevelopmental outcome. However, less is known about acquired...
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Article
Early predictors of neurodevelopment after perinatal arterial ischemic stroke: a systematic review and meta-analysis
Perinatal arterial ischemic stroke (PAIS) often has lifelong neurodevelopmental consequences. We aimed to review early predictors (<4 months of age) of long-term outcome.
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Article
The influence of nutrition on white matter development in preterm infants: a sco** review
White matter (WM) injury is the most common type of brain injury in preterm infants and is associated with impaired neurodevelopmental outcome (NDO). Currently, there are no treatments for WM injury, but optim...
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Article
Open AccessPostnatal serum IGF-1 levels associate with brain volumes at term in extremely preterm infants
Growth factors important for normal brain development are low in preterm infants. This study investigated the link between growth factors and preterm brain volumes at term.
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Article
Open AccessMammillary body injury in neonatal encephalopathy: a multicentre, retrospective study
The mammillary bodies (MBs) have repeatedly been shown to be critical for memory, yet little is known about their involvement in numerous neurological conditions linked to memory impairments, including neonata...
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Article
Post-hemorrhagic ventricular dilatation affects white matter maturation in extremely preterm infants
Data on microstructural white matter integrity in preterm infants with post-hemorrhagic ventricular dilatation (PHVD) using diffusion tensor imaging (DTI) are limited. Also, to date, no study has focused on th...
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Article
Sensory-based interventions in the NICU: systematic review of effects on preterm brain development
Infants born preterm are known to be at risk for abnormal brain development and adverse neurobehavioral outcomes. To improve early neurodevelopment, several non-pharmacological interventions have been develope...
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Article
Brain proton magnetic resonance spectroscopy and neurodevelopment after preterm birth: a systematic review
Preterm infants are at risk of neurodevelopmental impairments. At present, proton magnetic resonance spectroscopy (1H-MRS) is used to evaluate brain metabolites in asphyxiated term infants. The aim of this review...
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Article
Serum docosahexaenoic acid levels are associated with brain volumes in extremely preterm born infants
Docosahexaenoic acid (DHA) and arachidonic acid (AA) are important for fetal brain growth and development. Our aim was to evaluate the association between serum DHA and AA levels and brain volumes in extremely...
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Article
Cerebellar injury in term neonates with hypoxic–ischemic encephalopathy is underestimated
Postmortem examinations frequently show cerebellar injury in infants with severe hypoxic–ischemic encephalopathy (HIE), while it is less well visible on MRI. The primary aim was to investigate the correlation ...
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Article
Open AccessNutriBrain: protocol for a randomised, double-blind, controlled trial to evaluate the effects of a nutritional product on brain integrity in preterm infants
The gut microbiota and the brain are connected through different mechanisms. Bacterial colonisation of the gut plays a substantial role in normal brain development, providing opportunities for nutritional neur...
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Article
Brain temperature of infants with neonatal encephalopathy following perinatal asphyxia calculated using magnetic resonance spectroscopy
Little is known about brain temperature of neonates during MRI. Brain temperature can be estimated non-invasively with proton Magnetic Resonance Spectroscopy (1H-MRS), but the most accurate 1H-MRS method has not ...
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Article
Early prediction of unilateral cerebral palsy in infants at risk: MRI versus the hand assessment for infants
Neonates with unilateral perinatal brain injury (UPBI) are at risk for develo** unilateral spastic cerebral palsy (USCP). This study compares several predictors for USCP later in life.
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Article
Open AccessThe development and validation of a cerebral ultrasound scoring system for infants with hypoxic-ischaemic encephalopathy
Hypoxic-ischaemic encephalopathy (HIE) is an important cause of morbidity and mortality in neonates. When the gold standard MRI is not feasible, cerebral ultrasound (CUS) might offer an alternative. In this st...
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Article
Open AccessEffect of allopurinol in addition to hypothermia treatment in neonates for hypoxic-ischemic brain injury on neurocognitive outcome (ALBINO): study protocol of a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III)
Perinatal asphyxia and resulting hypoxic-ischemic encephalopathy is a major cause of death and long-term disability in term born neonates. Up to 20,000 infants each year are affected by HIE in Europe and even ...
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Article
Mild cerebellar injury does not significantly affect cerebral white matter microstructural organization and neurodevelopmental outcome in a contemporary cohort of preterm infants
Preterm birth is associated with an increased risk of cerebellar injury. The aim of this study was to assess the impact of cerebellar hemorrhages (CBH) on cerebral white matter microstructural tissue organizat...
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Article
Severe retinopathy of prematurity is associated with reduced cerebellar and brainstem volumes at term and neurodevelopmental deficits at 2 years
To evaluate the association between severe retinopathy of prematurity (ROP), measures of brain morphology at term-equivalent age (TEA), and neurodevelopmental outcome.
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Article
Changes in brain morphology and microstructure in relation to early brain activity in extremely preterm infants
To investigate the relation of early brain activity with structural (growth of the cortex and cerebellum) and white matter microstructural brain development.
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Article
Effects of early nutrition and growth on brain volumes, white matter microstructure, and neurodevelopmental outcome in preterm newborns
This study aimed to investigate the effect of nutrition and growth during the first 4 weeks after birth on cerebral volumes and white matter maturation at term equivalent age (TEA) and on neurodevelopmental ou...
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Article
Promoting neuroregeneration after perinatal arterial ischemic stroke: neurotrophic factors and mesenchymal stem cells
Newborns suffering from perinatal arterial ischemic stroke (PAIS) are at risk of neurodevelopmental problems. Current treatment options for PAIS are limited and mainly focus on supportive care, as presentation...
