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Neonatal encephalopathy and hypoxic–ischemic encephalopathy: moving from controversy to consensus definitions and subclassification
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Do we need a brain MRI once or twice in infants treated with hypothermia?
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Open AccessRapid exome sequencing as a first-tier test in neonates with suspected genetic disorder: results of a prospective multicenter clinical utility study in the Netherlands
The introduction of rapid exome sequencing (rES) for critically ill neonates admitted to the neonatal intensive care unit has made it possible to impact clinical decision-making. Unbiased prospective studies t...
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Open AccessWhy monitor the neonatal brain—that is the important question
A key goal of neonatal neurocritical care is improved outcomes, and brain monitoring plays an essential role. The recent NEST trial1 reported no outcome benefits using aEEG monitoring compared to clinical seizure...
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Open AccessMammillary body injury in neonatal encephalopathy: a multicentre, retrospective study
The mammillary bodies (MBs) have repeatedly been shown to be critical for memory, yet little is known about their involvement in numerous neurological conditions linked to memory impairments, including neonata...
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Post-hemorrhagic ventricular dilatation affects white matter maturation in extremely preterm infants
Data on microstructural white matter integrity in preterm infants with post-hemorrhagic ventricular dilatation (PHVD) using diffusion tensor imaging (DTI) are limited. Also, to date, no study has focused on th...
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Brain proton magnetic resonance spectroscopy and neurodevelopment after preterm birth: a systematic review
Preterm infants are at risk of neurodevelopmental impairments. At present, proton magnetic resonance spectroscopy (1H-MRS) is used to evaluate brain metabolites in asphyxiated term infants. The aim of this review...
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Training in neonatal neurocritical care: a proposal for a hybrid model of competence by design and time-based methods
Neonatal neurocritical care (NNCC) is a rapidly advancing field with limited fellowship training available in locally developed, non-accredited programs. A standardized survey aimed to understand the training ...
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Fronto-temporal horn ratio: yet another marker of ventriculomegaly?
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Cerebellar injury in term neonates with hypoxic–ischemic encephalopathy is underestimated
Postmortem examinations frequently show cerebellar injury in infants with severe hypoxic–ischemic encephalopathy (HIE), while it is less well visible on MRI. The primary aim was to investigate the correlation ...
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White matter injury in infants with intraventricular haemorrhage: mechanisms and therapies
Intraventricular haemorrhage (IVH) continues to be a major complication of prematurity that can result in cerebral palsy and cognitive impairment in survivors. No optimal therapy exists to prevent IVH or to tr...
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Open AccessMammillary body atrophy and other MRI correlates of school-age outcome following neonatal hypoxic-ischemic encephalopathy
The mammillary bodies (MB) and hippocampi are important for memory function and are often affected following neonatal hypoxic ischemic encephalopathy (HIE). The aim of this study was to assess neurodevelopment...
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Early prediction of unilateral cerebral palsy in infants at risk: MRI versus the hand assessment for infants
Neonates with unilateral perinatal brain injury (UPBI) are at risk for develo** unilateral spastic cerebral palsy (USCP). This study compares several predictors for USCP later in life.
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Open AccessThe development and validation of a cerebral ultrasound scoring system for infants with hypoxic-ischaemic encephalopathy
Hypoxic-ischaemic encephalopathy (HIE) is an important cause of morbidity and mortality in neonates. When the gold standard MRI is not feasible, cerebral ultrasound (CUS) might offer an alternative. In this st...
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Open AccessTwo-dimensional ultrasound measurements vs. magnetic resonance imaging-derived ventricular volume of preterm infants with germinal matrix intraventricular haemorrhage
Post-haemorrhagic ventricular dilatation can be measured accurately by MRI. However, two-dimensional (2-D) cranial US can be used at the bedside on a daily basis.
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The long-term effect of perinatal asphyxia on hippocampal volumes
Hypoxic–ischemic encephalopathy (HIE) in term-born infants can lead to memory problems. The hippocampus is important for long-term episodic memory. The primary aim was to investigate the effect of HIE on hippo...
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Early human brain development: insights into macroscale connectome wiring
Early brain development is closely dictated by distinct neurobiological principles. Here, we aimed to map early trajectories of structural brain wiring in the neonatal brain.
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Mild cerebellar injury does not significantly affect cerebral white matter microstructural organization and neurodevelopmental outcome in a contemporary cohort of preterm infants
Preterm birth is associated with an increased risk of cerebellar injury. The aim of this study was to assess the impact of cerebellar hemorrhages (CBH) on cerebral white matter microstructural tissue organizat...
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Severe retinopathy of prematurity is associated with reduced cerebellar and brainstem volumes at term and neurodevelopmental deficits at 2 years
To evaluate the association between severe retinopathy of prematurity (ROP), measures of brain morphology at term-equivalent age (TEA), and neurodevelopmental outcome.
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Changes in brain morphology and microstructure in relation to early brain activity in extremely preterm infants
To investigate the relation of early brain activity with structural (growth of the cortex and cerebellum) and white matter microstructural brain development.
